Nitte University Centre for Science Education and Research, Nitte (Deemed to be University), Mangaluru, India.
Crit Rev Microbiol. 2019 Sep-Nov;45(5-6):701-711. doi: 10.1080/1040841X.2019.1691973. Epub 2019 Nov 27.
Increasing levels of resistance to antimicrobial agents have created chaos in the health sector, with several infections not responding to antibiotic treatments. Search for alternative strategies has looked at bacteriophages as potential therapeutics and in the last couple of years. There are reports of phages being successfully used to treat life-threatening infections. Phages are also mobile elements that exchange genes between and within different bacterial species and account significantly for strain differences across and within a species. A gap in metagenomics analysis and conservative methods of detection have failed to give an accurate account of the role of bacteriophages in antimicrobial resistance. Recent studies have focussed on the role of bacteriophages in the adaptation of pathogens to new hosts and the emergence of multidrug-resistance, which are a significant concern against phage therapy. This article presents a comprehensive account of weighing the odds of phage therapy verses phage-mediated antimicrobial resistance.
抗菌药物耐药性的不断增强给卫生部门带来了混乱，许多感染对抗生素治疗没有反应。在过去几年中，人们一直在寻找替代策略，将噬菌体作为潜在的治疗方法。有报道称噬菌体成功地用于治疗危及生命的感染。噬菌体也是移动元件，它们在不同细菌物种之间和内部交换基因，并在物种之间和内部显著导致菌株差异。宏基因组分析中的空白和保守的检测方法未能准确说明噬菌体在抗菌药物耐药性中的作用。最近的研究集中在噬菌体在病原体适应新宿主和多药耐药性出现方面的作用，这是噬菌体治疗的一个重大关注点。本文全面论述了噬菌体治疗与噬菌体介导的抗菌药物耐药性之间的权衡。
