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颞下减压术在严重闭合性颅脑损伤中的作用

Role of subtemporal decompression in severe closed head injury.

作者信息

Gower D J, Lee K S, McWhorter J M

机构信息

Department of Surgery, Bowman Gray School of Medicine, Wake Forest University Medical Center, Winston Salem, North Carolina.

出版信息

Neurosurgery. 1988 Oct;23(4):417-22. doi: 10.1227/00006123-198810000-00002.

Abstract

There is general agreement that aggressive management and monitoring of the patient with closed head injury with control of intracranial pressure (ICP) will improve patient survival and eventual outcome. Conversely, there is little agreement on the value of surgical craniectomy for increasing intracranial volume and subsequently decreasing ICP in these same patients. This study examines 115 patients with severe closed head injuries (Glasgow Coma Score 8 or less) seen at the North Carolina Baptist Hospital between July 1, 1983, and April 1, 1987. All 115 patients were started on a regimen of head elevation, fluid restriction, chemoparalysis, and hyperventilation at PCO2 25-30 torr. Fifty-seven patients failed to respond to that therapy and were given mannitol. Twenty-seven of these still failed to respond; 24 were placed in a pentobarbital coma therapy group and 3 underwent subtemporal decompression. Of the 24 patients in pentobarbital coma, 17 failed to respond, 7 of whom underwent subtemporal decompression and 10 of whom were not operated on. Of all 10 patients undergoing subtemporal decompression, 7 (70%) responded with an average reduction in ICP of 34% (+/- 19.5% SD). Of the 10, 4 died (40%), in contrast with a mortality of 82.4% among patients in pentobarbital coma without subtemporal decompression. These data strongly suggest that subtemporal decompression can be beneficial in patients with medically intractable elevations of ICP.

摘要

人们普遍认为,对闭合性颅脑损伤患者进行积极的管理和监测,并控制颅内压(ICP),将提高患者的生存率和最终预后。相反,对于在这些相同患者中通过手术颅骨切除术增加颅内容积并随后降低ICP的价值,人们几乎没有共识。本研究检查了1983年7月1日至1987年4月1日期间在北卡罗来纳浸信会医院就诊的115例重度闭合性颅脑损伤患者(格拉斯哥昏迷评分8分或更低)。所有115例患者均开始采用抬高床头、限制液体摄入、化学麻痹和PCO2为25 - 30托的过度通气方案。57例患者对该治疗无反应,给予甘露醇治疗。其中27例仍无反应;24例被纳入戊巴比妥昏迷治疗组,3例接受颞下减压术。在24例接受戊巴比妥昏迷治疗的患者中,17例无反应,其中7例接受了颞下减压术,10例未进行手术。在所有10例接受颞下减压术的患者中,7例(70%)有反应,ICP平均降低34%(±19.5%标准差)。在这10例患者中,4例死亡(40%),相比之下,未进行颞下减压术的戊巴比妥昏迷患者死亡率为82.4%。这些数据强烈表明,颞下减压术对药物治疗难以控制ICP升高的患者可能有益。

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