Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
Curr Opin Obstet Gynecol. 2020 Apr;32(2):107-112. doi: 10.1097/GCO.0000000000000608.
Recent evidence supports elective induction of labor after 39 weeks; however, labor induction in patients with an unfavorable cervix, a Bishop score less than 6, may take several days. In this review, we focus on the efficacy and safety of methods of labor induction for the unfavorable cervix.
Recent evidence on the use of mechanical cervical preparation with transcervical balloons suggests balloons are the most effective option for decreasing time to delivery in the nulliparous patient. Single and double balloons are equally effective, with a volume of more 30 ml being more effective. The addition of misoprostol or oxytocin concurrently with a balloon further expedites time to delivery.
Mechanical dilation should be considered when available and technically possible for labor induction in patients with an unfavorable cervix. Misoprostol is an effective adjunct to trans-cervical balloons, further decreasing time to delivery as compared with balloon alone. When misoprostol is contraindicated, oxytocin is a safe, effective, alternative adjunct to trans-cervical balloons. More research is needed to evaluate safe outpatient options, induction methods in the setting of prior cesarean with an unfavorable cervix, and to directly compare misoprostol with oxytocin as adjuncts to transcervical balloons.
最近的证据支持在 39 周后择期引产;然而,对于宫颈条件不佳(Bishop 评分<6)的患者,引产可能需要数天。在本次综述中,我们重点关注对宫颈条件不佳患者进行引产的各种方法的疗效和安全性。
最近有证据表明,经宫颈使用球囊机械性扩张可有效缩短初产妇的产程。单球囊和双球囊同样有效,球囊容量超过 30ml 时效果更佳。球囊同时联合米索前列醇或缩宫素使用可进一步加快产程。
对于宫颈条件不佳的患者,在可行和技术上可能的情况下,应考虑使用机械扩张法进行引产。米索前列醇是经宫颈球囊的有效辅助用药,与单独使用球囊相比,可进一步缩短产程。当米索前列醇禁忌时,缩宫素是经宫颈球囊的一种安全、有效的替代辅助用药。需要更多的研究来评估安全的门诊选择、有剖宫产史的宫颈条件不佳患者的引产方法,以及直接比较米索前列醇与缩宫素作为经宫颈球囊的辅助用药。