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门诊引产——球囊导管是一种合适的方法吗?

Outpatient Induction of Labor - Are Balloon Catheters an Appropriate Method?

作者信息

Rath Werner, Stelzl Patrick, Kehl Sven

机构信息

Medizinische Fakultät, Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Universitätsklinik für Gynäkologie, Geburtshilfe und Gynäkologische Endokrinologie, Kepler Universitätsklinikum, Johannes Kepler Universität Linz, Linz, Austria.

出版信息

Geburtshilfe Frauenheilkd. 2021 Jan;81(1):70-80. doi: 10.1055/a-1308-2341. Epub 2021 Jan 19.

Abstract

As the number of labor inductions in high-income countries has steadily risen, hospital costs and the additional burden on obstetric staff have also increased. Outpatient induction of labor is therefore becoming increasingly important. It has been estimated that 20 - 50% of all pregnant women requiring induction would be eligible for outpatient induction. The use of balloon catheters in patients with an unripe cervix has been shown to be an effective and safe method of cervical priming. Balloon catheters are as effective as the vaginal administration of prostaglandin E or oral misoprostol. The advantage of using a balloon catheter is that it avoids uterine hyperstimulation and monitoring is less expensive. This makes balloon catheters a suitable option for outpatient cervical ripening. Admittedly, intravenous administration of oxytocin to induce or augment labor is required in approximately 75% of cases. Balloon catheters are not associated with a higher risk of maternal and neonatal infection compared to vaginal PGE . Low-risk pregnancies (e.g., post-term pregnancies, gestational diabetes) are suitable for outpatient cervical ripening with a balloon catheter. The data for high-risk pregnancies are still insufficient. The following conditions are recommended when considering an outpatient approach: strict selection of appropriate patients (singleton pregnancy, cephalic presentation, intact membranes), CTG monitoring for 20 - 40 minutes after balloon placement, the patient must be given detailed instructions about the indications for immediate readmission to hospital, and 24-hour phone access to the hospital must be ensured. According to reviewed studies, the balloon catheter remained in place between 12 hours ("overnight") and 24 hours. The most common reason for readmission to hospital was expulsion of the balloon catheter. The advantages of outpatient versus inpatient induction of cervical ripening with a balloon catheter were the significantly shorter hospital stay, the lower costs, and higher patient satisfaction, with both procedures having been shown to be equally effective. Complication rates (e.g., vaginal bleeding, severe pain, uterine hyperstimulation syndrome) during the cervical ripening phase are low (0.3 - 1.5%); severe adverse outcomes (e.g., placental abruption) have not been reported. Compared to inpatient induction of labor using vaginal PGE , outpatient cervical ripening using a balloon catheter had a lower rate of deliveries/24 hours and a significantly higher need for oxytocin; however, hospital stay was significantly shorter, frequency of pain during the cervical ripening phase was significantly lower, and patients' duration of sleep was longer. A randomized controlled study comparing outpatient cervical priming with a balloon catheter with outpatient or inpatient induction of labor with oral misoprostol would be of clinical interest.

摘要

随着高收入国家引产数量稳步上升,医院成本以及产科工作人员的额外负担也有所增加。因此,门诊引产变得越来越重要。据估计,所有需要引产的孕妇中有20%-50%适合门诊引产。对于宫颈未成熟的患者,使用球囊导管已被证明是一种有效且安全的宫颈预处理方法。球囊导管与阴道给予前列腺素E或口服米索前列醇一样有效。使用球囊导管的优点是可避免子宫过度刺激,且监测成本较低。这使得球囊导管成为门诊宫颈成熟的合适选择。诚然,大约75%的病例需要静脉注射缩宫素以引产或加强宫缩。与阴道给予前列腺素E相比,球囊导管与孕产妇和新生儿感染风险较高无关。低风险妊娠(如过期妊娠、妊娠期糖尿病)适合使用球囊导管进行门诊宫颈成熟。高风险妊娠的数据仍然不足。考虑门诊引产方法时,建议如下条件:严格挑选合适患者(单胎妊娠、头先露、胎膜完整),放置球囊后进行20-40分钟的胎心监护,必须向患者详细说明立即再次入院的指征,并且必须确保患者24小时可联系到医院。根据综述研究,球囊导管留置时间为12小时(“过夜”)至24小时。再次入院的最常见原因是球囊导管排出。与住院使用球囊导管进行宫颈成熟引产相比,门诊引产的优点是住院时间显著缩短、成本较低且患者满意度较高,两种方法均已证明效果相同。宫颈成熟阶段的并发症发生率(如阴道出血、剧痛、子宫过度刺激综合征)较低(0.3%-1.5%);尚未报告严重不良后果(如胎盘早剥)。与住院使用阴道前列腺素E引产相比,门诊使用球囊导管进行宫颈成熟的分娩率/24小时较低,缩宫素需求量显著更高;然而,住院时间显著缩短,宫颈成熟阶段的疼痛频率显著降低,患者睡眠时间更长。一项比较门诊使用球囊导管进行宫颈预处理与门诊或住院使用米索前列醇引产的随机对照研究将具有临床意义。

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