CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; School of Public Health, Qingdao University, Qingdao 226021, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China; Beijing Key Laboratory of Ionic Liquids Clean Process, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
J Control Release. 2020 Apr 10;320:293-303. doi: 10.1016/j.jconrel.2020.01.053. Epub 2020 Jan 28.
Treatment of solid tumors by chemotherapy is usually failed in clinical because of its low effectiveness and side effects. Stimulation of immune system in vivo to fight cancer has been proved to be a pleasant complementary to systemic chemotherapy. Herein, we have developed a combination cancer therapy strategy by using polymer nanoparticles to deliver Gd-metallofullerenol and doxorubicin simultaneously. The Gd-metallofullerenol provoked the Th1 immune response by regulating the M1 macrophage polarization and the doxorubicin realized direct tumor cells killing by its cytotoxic effect. Also, the Gd-metallofullerenol as part of component in delivery system enhances the encapsulation efficiency of doxorubicin in polymer cargo for potential passive tumor target. The biocompatible and reliable method by combining nanoparticle-induced immune modulation and chemotherapy triggers systemic antitumor immune responses for the synergistic inhibition of tumor growth in vivo. The integration of Gd-metallofullerenol and doxorubicin with potentially complementary functions in one nanoplatform may provide new opportunities to improve cancer treatments.
由于疗效低和副作用等问题，化疗在临床上通常无法有效治疗实体肿瘤。体内免疫系统刺激已被证明是一种对抗癌症的有效辅助治疗方法。本研究采用聚合物纳米粒子同时递送 Gd 金属富勒醇和阿霉素，开发了一种联合癌症治疗策略。Gd 金属富勒醇通过调节 M1 巨噬细胞极化引发 Th1 免疫反应，阿霉素通过其细胞毒性作用直接杀伤肿瘤细胞。此外，作为递送系统组成部分的 Gd 金属富勒醇提高了聚合物载体中阿霉素的包封效率，以实现潜在的被动肿瘤靶向。通过将纳米颗粒诱导的免疫调节和化疗相结合的这种具有生物相容性和可靠性的方法，在体内引发了系统抗肿瘤免疫反应，从而协同抑制肿瘤生长。将 Gd 金属富勒醇和阿霉素的潜在互补功能整合在一个纳米平台中，可能为改善癌症治疗提供新的机会。
