• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

工程化巨噬细胞来源的氧化铁纳米颗粒外泌体用于靶向病理性血管生成治疗

Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy.

作者信息

Zhang Haorui, Mao Yu, Nie Zheng, Li Qing, Wang Mengzhu, Cai Chang, Hao Weiju, Shen Xi, Gu Ning, Shen Wei, Song Hongyuan

机构信息

Department of Ophthalmology, Shanghai Changhai Hospital, Shanghai 200433, P.R. China.

Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210093, P.R. China.

出版信息

ACS Nano. 2024 Mar 12;18(10):7644-7655. doi: 10.1021/acsnano.4c00699. Epub 2024 Feb 27.

DOI:10.1021/acsnano.4c00699
PMID:38412252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10938920/
Abstract

Engineering exosomes with nanomaterials usually leads to the damage of exosomal membrane and bioactive molecules. Here, pathological angiogenesis targeting exosomes with magnetic imaging, ferroptosis inducing, and immunotherapeutic properties is fabricated using a simple coincubation method with macrophages being the bioreactor. Extremely small iron oxide nanoparticle (ESIONPs) incorporated exosomes (ESIONPs@EXO) are acquired by sorting the secreted exosomes from M1-polarized macrophages induced by ESIONPs. ESIONPs@EXO suppress pathological angiogenesis and without toxicity. Furthermore, ESIONPs@EXO target pathological angiogenesis and exhibit an excellent T1-weighted contrast property for magnetic resonance imaging. Mechanistically, ESIONPs@EXO induce ferroptosis and exhibit immunotherapeutic ability toward pathological angiogenesis. These findings demonstrate that a pure biological method engineered ESIONPs@EXO using macrophages shows potential for targeted pathological angiogenesis therapy.

摘要

用纳米材料对细胞外囊泡进行工程改造通常会导致细胞外囊泡膜和生物活性分子受损。在此，利用巨噬细胞作为生物反应器的简单共孵育方法制备了具有磁成像、铁死亡诱导和免疫治疗特性的靶向病理性血管生成的细胞外囊泡。通过对由极小的氧化铁纳米颗粒（ESIONPs）诱导的M1极化巨噬细胞分泌的细胞外囊泡进行分选，获得了包载ESIONPs的细胞外囊泡（ESIONPs@EXO）。ESIONPs@EXO可抑制病理性血管生成且无毒性。此外，ESIONPs@EXO靶向病理性血管生成，并在磁共振成像中表现出优异的T1加权对比特性。从机制上讲，ESIONPs@EXO诱导铁死亡，并对病理性血管生成表现出免疫治疗能力。这些发现表明，使用巨噬细胞通过纯生物学方法工程改造的ESIONPs@EXO在靶向病理性血管生成治疗方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/3e0e396ca6df/nn4c00699_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/c1dd5f1d197d/nn4c00699_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/abf90339dfb0/nn4c00699_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/4baf94625f0f/nn4c00699_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/80e1efd82f4f/nn4c00699_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/ed331b357541/nn4c00699_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/42d5e1fdfe4b/nn4c00699_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/3e0e396ca6df/nn4c00699_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/c1dd5f1d197d/nn4c00699_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/abf90339dfb0/nn4c00699_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/4baf94625f0f/nn4c00699_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/80e1efd82f4f/nn4c00699_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/ed331b357541/nn4c00699_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/42d5e1fdfe4b/nn4c00699_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f125/10938920/3e0e396ca6df/nn4c00699_0007.jpg

相似文献

1
Iron Oxide Nanoparticles Engineered Macrophage-Derived Exosomes for Targeted Pathological Angiogenesis Therapy.工程化巨噬细胞来源的氧化铁纳米颗粒外泌体用于靶向病理性血管生成治疗
ACS Nano. 2024 Mar 12;18(10):7644-7655. doi: 10.1021/acsnano.4c00699. Epub 2024 Feb 27.
2
Comparative transcriptomics revealed neurodevelopmental impairments and ferroptosis induced by extremely small iron oxide nanoparticles.比较转录组学揭示了极小微粒氧化铁纳米颗粒诱导的神经发育损伤和铁死亡。
Front Genet. 2024 May 17;15:1402771. doi: 10.3389/fgene.2024.1402771. eCollection 2024.
3
Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.胃癌衍生的外泌体 miR-519a-3p 通过诱导肝内 M2 样巨噬细胞介导的血管生成促进肝转移。
J Exp Clin Cancer Res. 2022 Oct 10;41(1):296. doi: 10.1186/s13046-022-02499-8.
4
Redox-triggered aggregation of ESIONPs with switchable to contrast effect for -weighted magnetic resonance imaging.基于氧化还原响应的 ESIONPs 聚集，具有可切换的 T1 加权磁共振成像对比效应。
J Mater Chem B. 2021 Feb 25;9(7):1821-1832. doi: 10.1039/d0tb02411b.
5
Synergistic regulation of longitudinal and transverse relaxivity of extremely small iron oxide nanoparticles (ESIONPs) using pH-responsive nanoassemblies.使用pH响应性纳米组装体对极小氧化铁纳米颗粒（ESIONPs）纵向和横向弛豫率的协同调控
Nanoscale. 2020 Aug 28;12(33):17502-17516. doi: 10.1039/d0nr04201c.
6
Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb.脂肪来源干细胞来源的外泌体诱导的巨噬细胞 M2 极化促进了外泌体对小鼠缺血后肢的促血管生成作用。
Stem Cell Res Ther. 2020 Apr 22;11(1):162. doi: 10.1186/s13287-020-01669-9.
7
S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis.S-RBD 修饰和 miR-486-5p 工程化间充质干细胞衍生的外泌体抑制铁死亡，减轻放射性肺损伤和长期肺纤维化。
J Nanobiotechnology. 2024 Oct 26;22(1):662. doi: 10.1186/s12951-024-02830-9.
8
Human serum-derived exosomes modulate macrophage inflammation to promote VCAM1-mediated angiogenesis and bone regeneration.人血清来源的外泌体调节巨噬细胞炎症，促进 VCAM1 介导线粒体生成和骨再生。
J Cell Mol Med. 2023 Apr;27(8):1131-1143. doi: 10.1111/jcmm.17727. Epub 2023 Mar 25.
9
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.负载曲古抑菌素A预处理的骨髓间充质干细胞衍生外泌体的胶原海绵支架调节巨噬细胞极化以促进皮肤伤口愈合。
Int J Biol Macromol. 2024 Jun;269(Pt 2):131948. doi: 10.1016/j.ijbiomac.2024.131948. Epub 2024 Apr 28.
10
M2 macrophage-derived exosomes induce angiogenesis and increase skin flap survival through HIF1AN/HIF-1α/VEGFA control.M2 巨噬细胞衍生的外泌体通过 HIF1AN/HIF-1α/VEGFA 控制诱导血管生成并增加皮瓣存活率。
Arch Biochem Biophys. 2024 Jan;751:109822. doi: 10.1016/j.abb.2023.109822. Epub 2023 Nov 27.

引用本文的文献

1
In vivo exosome imaging: applications of diverse visualization techniques.体内外泌体成像：多种可视化技术的应用
BMB Rep. 2025 Aug;58(8):340-349.
2
Inorganic nanomaterials as promising therapeutic agents for ocular neovascularization: Progress and perspectives.无机纳米材料作为治疗眼部新生血管的有前景的治疗剂：进展与展望
Mater Today Bio. 2025 Jul 4;33:102051. doi: 10.1016/j.mtbio.2025.102051. eCollection 2025 Aug.
3
Recent advances in engineered exosome-based therapies for ocular vascular disease.基于工程外泌体的眼部血管疾病治疗的最新进展

本文引用的文献

1
Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury.靶向抑制 CX3CL1 可抑制足细胞铁死亡从而减轻顺铂诱导的急性肾损伤。
Mol Med. 2023 Oct 24;29(1):140. doi: 10.1186/s10020-023-00733-3.
2
A Semiconducting Iron-Chelating Nano-immunomodulator for Specific and Sensitized Sono-metallo-immunotherapy of Cancer.一种用于癌症特异性致敏超声金属免疫疗法的半导体铁螯合纳米免疫调节剂。
Angew Chem Int Ed Engl. 2023 Oct 23;62(43):e202310178. doi: 10.1002/anie.202310178. Epub 2023 Sep 18.
3
CX3CL1 promotes M1 macrophage polarization and osteoclast differentiation through NF-κB signaling pathway in ankylosing spondylitis in vitro.
J Nanobiotechnology. 2025 Jul 19;23(1):526. doi: 10.1186/s12951-025-03589-3.
4
Modulation of the immune microenvironment using nanomaterials: a new strategy for tumor immunotherapy.利用纳米材料调控免疫微环境：肿瘤免疫治疗的新策略。
Front Immunol. 2025 Jul 2;16:1614640. doi: 10.3389/fimmu.2025.1614640. eCollection 2025.
5
A tandem-unlocked cascade nanoreactor for high-contrast magnetic resonance imaging-guided enhanced ferroptosis-chemo synergistic therapy.用于高对比度磁共振成像引导的增强型铁死亡-化学协同治疗的串联解锁级联纳米反应器
Mater Today Bio. 2025 May 10;32:101852. doi: 10.1016/j.mtbio.2025.101852. eCollection 2025 Jun.
6
Exosomes in cancer nanomedicine: biotechnological advancements and innovations.癌症纳米医学中的外泌体：生物技术进展与创新
Mol Cancer. 2025 Jun 7;24(1):166. doi: 10.1186/s12943-025-02372-0.
7
Macrophage-Derived Extracellular Vesicles: A Novel Therapeutic Alternative for Diabetic Wound.巨噬细胞衍生的细胞外囊泡：糖尿病伤口的一种新型治疗选择
Int J Nanomedicine. 2025 May 4;20:5763-5777. doi: 10.2147/IJN.S518655. eCollection 2025.
8
Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy.用于癌症免疫治疗的仿生纳米递送系统的最新进展。
Mater Today Bio. 2025 Apr 5;32:101726. doi: 10.1016/j.mtbio.2025.101726. eCollection 2025 Jun.
9
Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2.外泌体传递的LUCAT1通过与IGF2BP2结合促进膀胱癌的干性转化和化疗耐药性。
J Exp Clin Cancer Res. 2025 Mar 3;44(1):80. doi: 10.1186/s13046-025-03330-w.
10
Frontier applications of retinal nanomedicine: progress, challenges and perspectives.视网膜纳米医学的前沿应用：进展、挑战与展望
J Nanobiotechnology. 2025 Feb 25;23(1):143. doi: 10.1186/s12951-025-03095-6.
CX3CL1 通过 NF-κB 信号通路促进强直性脊柱炎体外 M1 巨噬细胞极化和破骨细胞分化。
J Transl Med. 2023 Aug 25;21(1):573. doi: 10.1186/s12967-023-04449-0.
4
Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases.最新进展与未来展望：眼内注射药物治疗玻璃体视网膜疾病的现状与挑战。
Adv Drug Deliv Rev. 2023 Jul;198:114870. doi: 10.1016/j.addr.2023.114870. Epub 2023 May 10.
5
Exosomes incorporated with black phosphorus quantum dots attenuate retinal angiogenesis via disrupting glucose metabolism.负载黑磷量子点的外泌体通过干扰葡萄糖代谢减轻视网膜血管生成。
Mater Today Bio. 2023 Mar 4;19:100602. doi: 10.1016/j.mtbio.2023.100602. eCollection 2023 Apr.
6
Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer.包载聚乙二醇化氧化铁纳米颗粒的脂质体可实现癌症中的铁死亡及联合治疗。
Natl Sci Rev. 2022 Aug 18;10(1):nwac167. doi: 10.1093/nsr/nwac167. eCollection 2023 Jan.
7
CCL3 aggravates intestinal damage in NEC by promoting macrophage chemotaxis and M1 macrophage polarization.CCL3 通过促进巨噬细胞趋化和 M1 巨噬细胞极化加重 NEC 中的肠道损伤。
Pediatr Res. 2023 Jul;94(1):119-128. doi: 10.1038/s41390-022-02409-w. Epub 2022 Dec 22.
8
Engineered Macrophages: A Safe-by-Design Approach for the Tumor Targeting Delivery of Sub-5 nm Gold Nanoparticles.工程化巨噬细胞：一种用于5纳米以下金纳米颗粒肿瘤靶向递送的设计安全方法。
Small. 2023 Jan;19(1):e2205474. doi: 10.1002/smll.202205474. Epub 2022 Nov 13.
9
Succinate and inosine coordinate innate immune response to bacterial infection.琥珀酸和肌苷协同调节先天免疫应答细菌感染。
PLoS Pathog. 2022 Aug 26;18(8):e1010796. doi: 10.1371/journal.ppat.1010796. eCollection 2022 Aug.
10
A Multifunctional Vanadium-Iron-Oxide Nanoparticle Eradicates Hepatocellular Carcinoma via Targeting Tumor and Endothelial Cells.多功能钒铁氧化物纳米颗粒通过靶向肿瘤细胞和内皮细胞根除肝癌。
ACS Appl Mater Interfaces. 2022 Jun 29;14(25):28514-28526. doi: 10.1021/acsami.2c03474. Epub 2022 Jun 13.