School of Biomedical Engineering, Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
Department of Radiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, China.
J Control Release. 2020 Apr 10;320:392-403. doi: 10.1016/j.jconrel.2020.01.048. Epub 2020 Jan 28.
Iron-based nanomaterials as the main ferroptosis-inducing platforms are more promising because iron itself is a key component in the Fenton reaction to produce ROS. However, the Fe dose needs to be very high in order to induce ferroptosis-based cancer treatment using the SPIO NPs. Therefore, it is still of great challenge to enhance the efficacy of ferroptosis-based cancer therapy by associating the iron-based nanomaterials with other components and therapeutic modalities. In this study, sorafenib (SRF) and ultrasmall SPIO nanoparticles were loaded into the mesopores and onto the surface of MPDA NPs to form SRF@MPDA-SPIO nanoparticles. SPIO loading endowed the system with iron-supply for ferroptosis and made the system MRI-visible. Meanwhile, SRF was able to induce ferroptosis in cancer cells with lower Fe dose. Furthermore, the heat generated by MPDA NPs upon laser irradiation offered a moderate PTT to boost the ferroptosis effect. The SRF@MPDA-SPIO exhibited biocompatibility highly desirable for in vivo application and superior anticancer therapy via the combination of ferroptosis and photothermal therapy.
铁基纳米材料作为主要的铁死亡诱导平台更有前途，因为铁本身是 Fenton 反应产生 ROS 的关键组成部分。然而，为了使用 SPIO NPs 诱导基于铁死亡的癌症治疗，需要非常高的 Fe 剂量。因此，通过将铁基纳米材料与其他成分和治疗方式结合来提高基于铁死亡的癌症治疗的疗效仍然是一个巨大的挑战。在本研究中，索拉非尼（SRF）和超小 SPIO 纳米颗粒被负载到介孔中和 MPDA NPs 的表面上，形成 SRF@MPDA-SPIO 纳米颗粒。SPIO 负载赋予了该系统铁供应以诱导铁死亡，并使该系统具有 MRI 可见性。同时，SRF 能够以较低的 Fe 剂量诱导癌细胞发生铁死亡。此外，MPDA NPs 在激光照射下产生的热量提供了适度的 PTT 以增强铁死亡效应。SRF@MPDA-SPIO 表现出高度理想的生物相容性，可用于体内应用，并且通过铁死亡和光热治疗的结合实现了优异的抗癌治疗效果。
