State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China.
J Mater Chem B. 2022 Aug 4;10(30):5784-5795. doi: 10.1039/d2tb01242a.
Ferroptosis, as a form of cell death different from apoptosis, is very promising for the treatment of cancer in nonapoptotic systems. Since iron is a key component in the induction of ferroptosis in cells, the use of iron-based nanomaterials in treating cancer through ferroptosis is of great significance. Therefore, in this study, magnetic nanoparticles (MNP) were coated with the zwitterionic polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), and then loaded with sorafenib (SRF) to obtain drug-loaded composite nanoparticles MNP@PMPC-SRF. FeO provided a large number of ferric/ferrous ions as an iron source, releasing Fe for the regulation of the ferroptosis process and enhancing the effect of the induced cellular ferroptosis on the treatment of colon cancer with SRF. The zwitterionic polymer PMPC effectively extended the blood circulation time, resulting in an enhanced tumor accumulation of the nanodrug. MNP@PMPC-SRF exhibited good biocompatibility for application and showed an excellent tumor inhibitory effect on HCT116 tumor-bearing nude mice.
铁死亡作为一种不同于细胞凋亡的细胞死亡形式，在非凋亡系统的癌症治疗中很有前途。由于铁是细胞中诱导铁死亡的关键成分，因此通过铁死亡使用铁基纳米材料治疗癌症具有重要意义。因此，在这项研究中，磁性纳米粒子（MNP）被涂覆了两性离子聚合物聚（2-甲基丙烯酰氧乙基磷酸胆碱）（PMPC），然后负载索拉非尼（SRF）以获得载药复合纳米粒子 MNP@PMPC-SRF。FeO 提供了大量的三价/二价铁离子作为铁源，释放出 Fe 以调节铁死亡过程，并增强了用 SRF 诱导细胞铁死亡对结肠癌的治疗效果。两性离子聚合物 PMPC 有效地延长了血液循环时间，导致纳米药物在肿瘤中的积累增强。MNP@PMPC-SRF 具有良好的应用生物相容性，并对 HCT116 荷瘤裸鼠表现出优异的肿瘤抑制作用。
