Yousfi Hanane, Ranque Stéphane, Cassagne Carole, Rolain Jean-Marc, Bittar Fadi
Aix-Marseille Université, IRD, APHM, MEPHI, Marseille, France; IHU-Méditerranée Infection, Marseille, France.
IHU-Méditerranée Infection, Marseille, France; Aix-Marseille Université, IRD, APHM, SSA, VITROME, Marseille, France.
J Glob Antimicrob Resist. 2020 Jun;21:314-317. doi: 10.1016/j.jgar.2020.01.002. Epub 2020 Jan 28.
The incidence of severe filamentous fungal infections has increased over the past decade. Some of these filamentous fungi are resistant to available antifungals; it is thus urgent to find new compounds that are active against such life-threatening pathogens.
In this study, 1280 drugs (Prestwick Chemical Library) were tested against six multidrug-resistant (MDR) filamentous fungi, includingAspergillus, Fusarium, Scedosporium/Lomentospora, Rhizopus and Lichtheimia species.
Several hits were identified that induced fungal growth inhibition ≥70%. Among the non-antifungal compounds that were effective against the clinical moulds tested in this study, clioquinol, alexidine dihydrochloride, hexachlorophene and thonzonium bromide displayed a broad activity against all strains tested.
This study enriches the potential antifungal options that can be used against MDR invasive fungal diseases.
在过去十年中，严重丝状真菌感染的发病率有所上升。其中一些丝状真菌对现有的抗真菌药物具有抗性；因此，迫切需要找到对这种危及生命的病原体具有活性的新化合物。
在本研究中，针对六种多重耐药（MDR）丝状真菌测试了1280种药物（普瑞思威克化学文库），这些真菌包括曲霉属、镰刀菌属、赛多孢属/洛蒙孢子菌属、根霉属和犁头霉属。
鉴定出了几种诱导真菌生长抑制率≥70%的活性药物。在本研究中对测试的临床霉菌有效的非抗真菌化合物中，氯碘羟喹、二盐酸阿来西定、六氯酚和溴化噻宗宁对所有测试菌株均表现出广泛的活性。
本研究丰富了可用于治疗多重耐药侵袭性真菌病的潜在抗真菌选择。
