APX001A 对罕见霉菌的体外活性：使用 EUCAST 和 CLSI 方法学。
In vitro activity of APX001A against rare moulds using EUCAST and CLSI methodologies.
机构信息
Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain; Spanish Network for the Research in Infectious Diseases (RD16/CIII/0004/0003), Instituto de Salud Carlos III, Madrid, Spain.
出版信息
J Antimicrob Chemother. 2019 May 1;74(5):1295-1299. doi: 10.1093/jac/dkz022.
BACKGROUND
APX001A (E1210) is a novel broad-spectrum antifungal agent that inhibits Gwt1p, a protein that plays an important role in fungal cell wall integrity. Previous studies have shown that APX001A has broad activity against most species of Candida, Aspergillus, Scedosporium, Fusarium and Mucorales.
OBJECTIVES
To investigate the in vitro activity of APX001A against 200 isolates belonging to 20 different species of Fusarium, Scedosporium, Lomentospora, Alternaria, cryptic species of Aspergillus and Mucorales.
METHODS
APX001A and comparators were tested using EUCAST and CLSI methodologies for broth microdilution susceptibility testing of antifungal agents.
RESULTS
APX001A was generally inactive against Mucorales, but active against all cryptic species of Aspergillus and Scedosporium/Lomentospora species.
CONCLUSIONS
APX001A shows encouraging in vitro activity against some emerging fungi that are hard to treat with currently available antifungals.
背景
APX001A（E1210）是一种新型广谱抗真菌药物，可抑制 Gwt1p，该蛋白在真菌细胞壁完整性中起着重要作用。先前的研究表明，APX001A 对大多数念珠菌属、曲霉菌属、枝孢菌属、镰刀菌属和毛霉目真菌具有广泛的活性。
目的
研究 APX001A 对 200 株属于 20 种不同镰刀菌属、枝孢菌属、节菱孢属、链格孢属、曲霉属隐种和毛霉目真菌的体外活性。
方法
采用 EUCAST 和 CLSI 方法，用肉汤微量稀释法检测抗真菌药物，对 APX001A 和对照药物进行检测。
结果
APX001A 一般对毛霉目真菌无活性，但对所有曲霉属隐种和枝孢菌属/节菱孢属真菌有活性。
结论
APX001A 对一些用现有抗真菌药物难以治疗的新型真菌表现出令人鼓舞的体外活性。
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