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羊膜移植联合Tenon 成形术治疗严重眼烧伤致前段缺血性坏死。

Tenonplasty Combined With Amniotic Membrane Transplantation for Patients With Severe Ocular Burns Induced Anterior Segment Necrosis.

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and GeneRegulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

J Burn Care Res. 2020 May 2;41(3):668-673. doi: 10.1093/jbcr/iraa016.

DOI:10.1093/jbcr/iraa016
PMID:32006003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7195555/
Abstract

This article describes a novel surgical technique for successful repair of intractable corneoscleral necrosis caused by severe ocular burns. In this prospective case series, 19 eyes of 15 consecutive patients with sectional scleral necrosis and persistent corneal epithelial defects were treated with tenonplasty and amniotic membrane transplantation. The main outcome measure was the stability of the ocular surface after reepithelialization and repair of defects. All patients underwent successful combined surgery involving tenonplasty and amniotic membrane transplantation, in which the conjunctival and corneal surfaces were reconstructed. The interval from injury to surgery was 37.4 ± 24.5 days (3-91 days), and the ocular surfaces became stabilized in 82.2 ± 35.4 days (26-156 days, median 87 days). At the final visit, all cases presented with corneal opacity and neovascularization to various degrees. The best-corrected visual acuity decreased from 2.83 ± 1.02 LogMAR preoperatively to 2.87 ± 1.31 LogMAR postoperatively. The results imply that tenonplasty combined with amniotic membrane transplantation could provide vascular supply to the ischemic sclera, repair defects in the conjunctiva, and promote corneal reepithelialization, thus facilitating ocular surface stabilization after burns.

摘要

本文介绍了一种治疗严重眼烧伤导致的难治性角巩膜坏死的新型手术技术。在这项前瞻性病例系列研究中,15 例连续患者的 19 只眼均因节段性巩膜坏死和持续性角膜上皮缺损而行板层巩膜成形术和羊膜移植术。主要观察指标为再上皮化和修复缺损后眼表的稳定性。所有患者均成功接受了涉及板层巩膜成形术和羊膜移植术的联合手术,其中重建了结膜和角膜表面。从损伤到手术的间隔为 37.4 ± 24.5 天(3-91 天),82.2 ± 35.4 天(26-156 天,中位数 87 天)后眼表稳定。最终随访时,所有病例均表现出不同程度的角膜混浊和新生血管形成。最佳矫正视力从术前的 2.83 ± 1.02 LogMAR 下降到术后的 2.87 ± 1.31 LogMAR。结果表明,板层巩膜成形术联合羊膜移植术可为缺血性巩膜提供血管供应,修复结膜缺损,并促进角膜再上皮化,从而促进烧伤后眼表稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/999060b455df/iraa016f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/33c758cb1b79/iraa016f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/042a9a360ec3/iraa016f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/999060b455df/iraa016f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/33c758cb1b79/iraa016f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/042a9a360ec3/iraa016f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/999060b455df/iraa016f0003.jpg

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本文引用的文献

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Comparison of umbilical cord serum and amniotic membrane transplantation in acute ocular chemical burns.急性眼化学伤中脐带血清与羊膜移植的比较
Br J Ophthalmol. 2015 May;99(5):669-73. doi: 10.1136/bjophthalmol-2014-305760. Epub 2014 Nov 4.
2
Surgical rehabilitation following ocular chemical injury.眼部化学伤后的手术康复
Cutan Ocul Toxicol. 2014 Mar;33(1):42-8. doi: 10.3109/15569527.2013.796477. Epub 2013 May 28.
3
Complications of keratolimbal allograft surgery.角膜缘异体移植手术的并发症。
联合脐带贴片与羊膜移植用于角膜表面重建。
Med Hypothesis Discov Innov Ophthalmol. 2022 Dec 3;11(3):129-136. doi: 10.51329/mehdiophthal1456. eCollection 2022 Fall.
4
The role of Tenonplasty in the management of limbal and scleral ischemia due to acute ocular chemical burns.Tenonplasty 在治疗因急性眼部化学灼伤导致的角膜缘和巩膜缺血中的作用。
Indian J Ophthalmol. 2022 Sep;70(9):3203-3212. doi: 10.4103/ijo.IJO_3148_21.
Cornea. 2013 May;32(5):561-6. doi: 10.1097/ICO.0b013e31826215eb.
4
Visual rehabilitation with keratoprosthesis after tenonplasty as the primary globe-saving procedure for severe ocular chemical injuries.眼内容剜除联合羊膜移植一期行角膜眼表重建术治疗严重眼化学伤
Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1787-93. doi: 10.1007/s00417-012-2030-8. Epub 2012 May 1.
5
A modified symblepharon ring for sutureless amniotic membrane patch to treat acute ocular surface burns.一种用于无缝合羊膜贴片治疗急性眼表烧伤的改良睑球粘连环。
J Burn Care Res. 2012 Mar-Apr;33(2):e32-8. doi: 10.1097/BCR.0b013e318239f9b9.
6
Amniotic membrane transplantation as an adjunct to medical therapy in acute ocular burns.羊膜移植在急性眼部烧伤的药物治疗中的辅助作用。
Br J Ophthalmol. 2011 Feb;95(2):199-204. doi: 10.1136/bjo.2009.173716. Epub 2010 Jul 31.
7
Management of ocular thermal and chemical injuries, including amniotic membrane therapy.眼热烧伤和化学伤的处理,包括羊膜治疗。
Curr Opin Ophthalmol. 2010 Jul;21(4):317-21. doi: 10.1097/ICU.0b013e32833a8da2.
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Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis.羊膜移植作为史蒂文斯-约翰逊综合征和中毒性表皮坏死松解症急性眼部表现的一种新疗法。
Surv Ophthalmol. 2009 Nov-Dec;54(6):686-96. doi: 10.1016/j.survophthal.2009.03.004. Epub 2009 Aug 21.
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Limbal stem cell transplantation: new progresses and challenges.角膜缘干细胞移植:新进展与挑战。
Eye (Lond). 2009 Oct;23(10):1946-53. doi: 10.1038/eye.2008.379. Epub 2008 Dec 19.
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Management of severe ocular burns with symblepharon.伴有睑球粘连的严重眼烧伤的处理
Graefes Arch Clin Exp Ophthalmol. 2009 Jan;247(1):101-6. doi: 10.1007/s00417-008-0934-0. Epub 2008 Sep 3.