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羊膜移植联合Tenon 成形术治疗严重眼烧伤致前段缺血性坏死。

Tenonplasty Combined With Amniotic Membrane Transplantation for Patients With Severe Ocular Burns Induced Anterior Segment Necrosis.

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and GeneRegulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

J Burn Care Res. 2020 May 2;41(3):668-673. doi: 10.1093/jbcr/iraa016.

Abstract

This article describes a novel surgical technique for successful repair of intractable corneoscleral necrosis caused by severe ocular burns. In this prospective case series, 19 eyes of 15 consecutive patients with sectional scleral necrosis and persistent corneal epithelial defects were treated with tenonplasty and amniotic membrane transplantation. The main outcome measure was the stability of the ocular surface after reepithelialization and repair of defects. All patients underwent successful combined surgery involving tenonplasty and amniotic membrane transplantation, in which the conjunctival and corneal surfaces were reconstructed. The interval from injury to surgery was 37.4 ± 24.5 days (3-91 days), and the ocular surfaces became stabilized in 82.2 ± 35.4 days (26-156 days, median 87 days). At the final visit, all cases presented with corneal opacity and neovascularization to various degrees. The best-corrected visual acuity decreased from 2.83 ± 1.02 LogMAR preoperatively to 2.87 ± 1.31 LogMAR postoperatively. The results imply that tenonplasty combined with amniotic membrane transplantation could provide vascular supply to the ischemic sclera, repair defects in the conjunctiva, and promote corneal reepithelialization, thus facilitating ocular surface stabilization after burns.

摘要

本文介绍了一种治疗严重眼烧伤导致的难治性角巩膜坏死的新型手术技术。在这项前瞻性病例系列研究中,15 例连续患者的 19 只眼均因节段性巩膜坏死和持续性角膜上皮缺损而行板层巩膜成形术和羊膜移植术。主要观察指标为再上皮化和修复缺损后眼表的稳定性。所有患者均成功接受了涉及板层巩膜成形术和羊膜移植术的联合手术,其中重建了结膜和角膜表面。从损伤到手术的间隔为 37.4 ± 24.5 天(3-91 天),82.2 ± 35.4 天(26-156 天,中位数 87 天)后眼表稳定。最终随访时,所有病例均表现出不同程度的角膜混浊和新生血管形成。最佳矫正视力从术前的 2.83 ± 1.02 LogMAR 下降到术后的 2.87 ± 1.31 LogMAR。结果表明,板层巩膜成形术联合羊膜移植术可为缺血性巩膜提供血管供应,修复结膜缺损,并促进角膜再上皮化,从而促进烧伤后眼表稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a26/7195555/33c758cb1b79/iraa016f0001.jpg

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