[一名老年男性中作为羟基磷灰石病表现的缓慢进行性关节破坏。病例报告及文献综述]

[Slowly progressive joint destruction in an older man as expression of hydroxyapatite disease. Case report and literature review].

作者信息

Zipfel N, Dießel L, Delank K-S, Keyßer G, Schäfer C

机构信息

Klinik für Innere Medizin II, Arbeitsbereich Rheumatologie, Universitätsklinikum Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.

Institut für Pathologie, Universitätsklinikum Halle (Saale), Halle (Saale), Deutschland.

出版信息

Z Rheumatol. 2020 Mar;79(2):195-199. doi: 10.1007/s00393-020-00745-y.

DOI:10.1007/s00393-020-00745-y

PMID:32006094

Abstract

This article reports the case of a 75-year-old male patient presenting with arthralgia of the large joints that had existed for 10 years. Clinically, bursitis of the right elbow joint was found. Laboratory tests showed elevated inflammatory markers and imaging revealed erosive joint destruction. A surgical bursectomy was performed. Histologically, hydroxyapatite crystals were detected in alizarin red S staining and a crystal arthropathy was diagnosed. The diagnostics are difficult since crystals can only be detected by electron microscopy or special staining methods.

摘要

本文报道了一名75岁男性患者的病例，该患者出现大关节疼痛已有10年。临床上，发现右肘关节滑囊炎。实验室检查显示炎症标志物升高，影像学检查显示关节侵蚀性破坏。进行了手术滑囊切除术。组织学检查发现，茜素红S染色检测到羟基磷灰石晶体，诊断为晶体性关节病。诊断困难，因为晶体只能通过电子显微镜或特殊染色方法检测到。