Valentine J M, Lyons G, Bellamy M C
Department of Anaesthesia, St James's University Hospital, Leeds, UK.
Eur J Anaesthesiol. 1996 Nov;13(6):589-93. doi: 10.1046/j.1365-2346.1996.00044.x.
Intrathecal midazolam for use as a post-operative analgesic when given alone and in conjunction with intrathecal diamorphine was assessed. Fifty-two patients scheduled for elective Caesarean section under spinal anaesthesia were randomly allocated to receive either bupivacaine (B), bupivacaine with diamorphine (BD), bupivacaine with midazolam (BM) or all three (BMD) by intrathecal injection. Post-operatively, no differences in visual analogue score (VAS), sedation or post-operative nausea and vomiting (PONV) could be demonstrated between groups. Patient-controlled analgesia system (PCAS) usage was significantly greater in group B when compared with the other groups. Pruritus was commoner in patients receiving diamorphine (BMD & BD). No side effects attributable to midazolam were identified. Intrathecal midazolam at this dose appears safe and has clinically detectable analgesic properties. The duration of useful analgesia appears to be short-lived.
对鞘内注射咪达唑仑单独使用及与鞘内注射二氢吗啡联合使用作为术后镇痛药物进行了评估。52例计划在脊髓麻醉下进行择期剖宫产的患者被随机分配，通过鞘内注射分别接受布比卡因（B）、布比卡因加二氢吗啡（BD）、布比卡因加咪达唑仑（BM）或三者联合（BMD）。术后，各组之间在视觉模拟评分（VAS）、镇静或术后恶心呕吐（PONV）方面未显示出差异。与其他组相比，B组患者自控镇痛系统（PCAS）的使用显著更多。接受二氢吗啡的患者（BMD和BD组）瘙痒更为常见。未发现归因于咪达唑仑的副作用。该剂量的鞘内注射咪达唑仑似乎是安全的，且具有临床可检测到的镇痛特性。有效镇痛的持续时间似乎较短。
