Chidambaram Saravana Babu, Bhat Abid, Mahalakshmi Arehally Marappa, Ray Bipul, Tuladhar Sunanda, Sushmitha B S, Saravanan B, Thamilarasan Manivasagam, Thenmozhi Arokiasamy Justin, Essa Musthafa Mohamed, Guillemin Gilles J, Qoronfleh M Walid
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India.
Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, India.
Adv Neurobiol. 2020;24:573-586. doi: 10.1007/978-3-030-30402-7_20.
Autism is a developmental disorder that affects communication and behavior. Although autism can be diagnosed at any age, it is said to be a "developmental disorder" because symptoms generally appear in the first 2 years of life. The primary cause of autism is still not clear and therapy is currently restricted to controlling behavioral abnormalities. However, emerging studies have shown a link between mitochondrial dysfunction and autism. Dietary supplements that promote mitochondrial biogenesis and inhibit the production of oxidative stress have been used to treat autism patients. Dietary adjustments in treating autism is a novel approach to suppress autistic symptoms. Supplementation with antioxidants has been found to not only inhibit cognitive decline but also improve behavioral symptoms in autism. Dietary supplements fortified with vitamins should only be given under the supervision of a physician. A wide range of nutraceuticals are under clinical trials to understand whether they physiologically target mitochondrial pathways and improve the quality of life in autism.
自闭症是一种影响沟通和行为的发育障碍。尽管自闭症可在任何年龄被诊断出来，但因其症状通常在生命的头两年出现，所以被称为“发育障碍”。自闭症的主要病因仍不明确，目前治疗仅限于控制行为异常。然而，新出现的研究表明线粒体功能障碍与自闭症之间存在联系。促进线粒体生物合成并抑制氧化应激产生的膳食补充剂已被用于治疗自闭症患者。通过饮食调整来治疗自闭症是一种抑制自闭症症状的新方法。已发现补充抗氧化剂不仅能抑制认知能力下降，还能改善自闭症患者的行为症状。含维生素的膳食补充剂应仅在医生的监督下服用。目前有多种营养保健品正在进行临床试验，以了解它们是否能从生理上针对线粒体途径并改善自闭症患者的生活质量。
