Chidambaram Saravana Babu, Tuladhar Sunanda, Bhat Abid, Mahalakshmi Arehally Marappa, Ray Bipul, Essa Musthafa Mohamed, Bishir Muhammed, Bolla Srinivasa Rao, Nanjaiah Nandakumar Dalavaikodihalli, Guillemin Gilles J, Qoronfleh M Walid
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, India.
Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru, India.
Adv Neurobiol. 2020;24:587-600. doi: 10.1007/978-3-030-30402-7_21.
Characterized by a wide range of behavioural, social and language problems, autism is a complex developmental disability that affects an individual's capacity to communicate and interact with others. Although the real causes that lead to the development of autism are still unclear, the gastrointestinal tract has been found to play a major role in the development of autism. Alterations in macrobiotic compositions have been reported in autistic children. Irregularities in carbohydrate digestion and absorption could also explain some of the gastrointestinal problems reported in autistic patients, although their role in the neurological and behavioural problems remains uncertain. A relationship between improved gut health and decrease of symptoms in autism has been reported as well. Studies done to evaluate the gluten-free diets, casein-free diets, pre- and probiotic and multivitamin supplementation have shown promising results. Probiotics have been thought to alleviate the progression of autism and reduce cognitive and behavioural deficits.
自闭症的特征是存在广泛的行为、社交和语言问题，它是一种复杂的发育障碍，会影响个体与他人沟通和互动的能力。尽管导致自闭症发展的真正原因仍不明确，但已发现胃肠道在自闭症的发展中起主要作用。据报道，自闭症儿童的肠道微生物组成发生了改变。碳水化合物消化和吸收的异常也可以解释自闭症患者报告的一些胃肠道问题，尽管它们在神经和行为问题中的作用仍不确定。也有报道称改善肠道健康与自闭症症状减轻之间存在关联。评估无麸质饮食、无酪蛋白饮食、益生菌和多种维生素补充剂的研究已显示出有希望的结果。益生菌被认为可以缓解自闭症的进展并减少认知和行为缺陷。
