University of Bielefeld, Germany; University of Bucharest, Romania; Oberberg Clinic Hornberg, Germany.
Oberberg Clinic Hornberg, Germany; University of Freiburg, Germany.
Neuropsychologia. 2020 Mar 2;139:107364. doi: 10.1016/j.neuropsychologia.2020.107364. Epub 2020 Jan 29.
Memory disorders without a direct neural substrate still belong to the riddles in neuroscience. Although they were for a while dissociated from research and clinical arenas, risking becoming forgotten diseases, they sparked novel interests, paralleling the refinements in functional neuroimaging and neuropsychology. Although Endel Tulving has not fully embarked himself on exploring this field, he had published at least one article on functional amnesia (Schacter et al., 1982) and ignited a seminal article on amnesia with mixed etiology (Craver et al., 2014). Most importantly, the research of Endel Tulving has provided the researchers and clinicians in the field of dissociative or functional amnesia with the best framework for superiorly understanding these disorders through the lens of his evolving concept of episodic memory and five long term memory systems classification, which he developed and advanced. Herein we use the classification of long-term memory systems of Endel Tulving as well as his concepts and views on autonoetic consciousness, relationships between memory systems and relationship between episodic memory and emotion to describe six cases of dissociative amnesia that put a challenge for researchers and clinicians due to their atypicality. We then discuss their possible triggering and maintaining mechanisms, pointing to their clinical heterogeneity and multifaceted causally explanatory frameworks.
尽管记忆障碍没有直接的神经基础,但它们仍然属于神经科学的未解之谜。尽管这些记忆障碍一度脱离了研究和临床领域,面临被遗忘的风险,但它们引发了新的兴趣,与功能神经影像学和神经心理学的精细化发展并行不悖。尽管恩德尔·图尔文(Endel Tulving)并没有完全涉足这个领域,但他至少发表过一篇关于功能性遗忘的文章(Schacter 等人,1982),并点燃了一篇关于混合病因遗忘症的开创性文章(Craver 等人,2014)。最重要的是,恩德尔·图尔文的研究为分离性或功能性遗忘症领域的研究人员和临床医生提供了最佳框架,通过他不断发展的情景记忆概念和五个长期记忆系统分类,来更好地理解这些障碍,他开发并推进了这些概念和分类。在此,我们使用恩德尔·图尔文的长期记忆系统分类以及他关于自主意识、记忆系统之间的关系以及情景记忆和情绪之间的关系的概念和观点,来描述六个因非典型性而给研究人员和临床医生带来挑战的分离性遗忘症病例。然后,我们讨论了它们可能的触发和维持机制,指出了它们的临床异质性和多方面的因果解释框架。