Boys Town National Research Hospital, Omaha, Nebraska 68131, USA.
J Acoust Soc Am. 2020 Jan;147(1):25. doi: 10.1121/10.0000493.
Use of the auditory brainstem response (ABR) in research has increased in the search for physiological correlates of noise-induced damage to the cochlea. The extraction of data from the ABR has traditionally relied on visual determination of peaks and troughs to calculate metrics such as wave amplitude. Visual determination can be reliable when evaluated by trained, experienced personnel, but noisy waveforms and overlapping waves produce uncertain data. The present study proposes and validates a method of fitting summed Gaussian functions to the summating potential and wave I of the ABR. This method could be useful to the research community studying these potentials by providing more accurate measures of wave amplitude than by visual determination.
在研究中使用听觉脑干反应（ABR）来寻找耳蜗噪声损伤的生理相关性的应用越来越多。ABR 数据的提取传统上依赖于视觉确定波峰和波谷来计算波幅等指标。当由经过训练的有经验的人员进行评估时，视觉确定是可靠的，但噪声波形和重叠的波会产生不确定的数据。本研究提出并验证了一种将高斯函数叠加到 ABR 的总和电位和波 I 上的拟合方法。通过提供比视觉确定更准确的波幅测量值，这种方法可能对研究这些电位的研究团体有用。
