Magnoni Marco, Scarano Paola, Vergani Vittoria, Berteotti Martina, Gallone Guglielmo, Cristell Nicole, Maseri Attilio, Cianflone Domenico
IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy.
IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy.
Nutr Metab Cardiovasc Dis. 2020 Apr 12;30(4):574-580. doi: 10.1016/j.numecd.2019.11.014. Epub 2019 Dec 6.
The Mediterranean diet (MD) affects the risk of myocardial infarction and long-term prognosis after a coronary event. Limited data are available regarding the influence of MD on short-term prognosis. We assessed the impact of the MD adherence on in-hospital and short-term outcome in patients with first ST-elevation Myocardial Infarction (STEMI).
As many as 533 European patients with STEMI and no previous history of coronary artery disease were included in this analysis. Previous dietary habits of each patient were collected with a food frequency questionnaire from which we calculated the FAMI Mediterranean Diet Score (FAMI MD Score), according to the MD adherence. A blood sample was drawn to each patient within 6 h of symptoms onset. Levels of high-sensitivity C-Reactive Protein (hsCRP), Interleukin-6 (IL-6) were measured. Clinical outcome at 180 days and myocardial reperfusion were assessed. Patients with higher FAMI MD Score had lower levels of hsCRP; there were no differences between IL-6 level among FAMI MD Score quintiles. There were no associations between adherence to MD and 180-day adverse events. Lower FAMI MD Score was associated with a higher risk of ineffective myocardial reperfusion after thrombolysis or percutaneous coronary intervention. Similar results were observed for daily consumption of ≥4 portions of fruit and vegetable.
A positive effect of the Mediterranean diet, and fruit and vegetable intake was observed on hsCRP and the occurrence of effective myocardial reperfusion. These findings confirm the favorable impact of Mediterranean diet adherence not only in primary but also in secondary prevention.
地中海饮食（MD）会影响心肌梗死风险以及冠状动脉事件后的长期预后。关于MD对短期预后影响的数据有限。我们评估了MD依从性对首次ST段抬高型心肌梗死（STEMI）患者住院期间及短期结局的影响。
本分析纳入了533例无冠状动脉疾病病史的欧洲STEMI患者。通过食物频率问卷收集每位患者既往的饮食习惯，并据此计算FAMI地中海饮食评分（FAMI MD评分），以评估MD依从性。在症状发作6小时内采集每位患者的血样，检测高敏C反应蛋白（hsCRP）、白细胞介素-6（IL-6）水平。评估180天时的临床结局及心肌再灌注情况。FAMI MD评分较高的患者hsCRP水平较低；FAMI MD评分五分位数组间的IL-6水平无差异。MD依从性与180天不良事件之间无关联。较低的FAMI MD评分与溶栓或经皮冠状动脉介入治疗后心肌再灌注无效的较高风险相关。每日食用≥4份水果和蔬菜也观察到类似结果。
观察到地中海饮食以及水果和蔬菜摄入对hsCRP及有效心肌再灌注的发生有积极影响。这些发现证实了坚持地中海饮食不仅在一级预防而且在二级预防中都有有利影响。
