Sewdarsen M, Vythilingum S, Jialal I, Nadar R
Ischaemic Heart Disease Clinic, R. K. Khan Hospital, Durban, South Africa.
Postgrad Med J. 1988 May;64(751):352-6. doi: 10.1136/pgmj.64.751.352.
Total serum cholesterol and triglycerides were measured in 159 Indian patients (134 males) with acute myocardial infarction during their stay in hospital (days 1 and 2) and 3 months later in order to assess whether lipid levels measured soon after acute myocardial infarction represent basal values. Early and 3 month lipid levels were also compared according to the sex and glucose tolerance of the patients. The mean total cholesterol levels on admission (day 1) were comparable to the 3 month values in both men (6.09 +/- 0.10 vs 6.18 +/- 0.09 mmol/l) and women (6.75 +/- 0.30 vs 6.44 +/- 0.22 mmol/l) irrespective of glucose tolerance. In the entire group cholesterol levels on day 2 were significantly lower than the admission and 3 month values. Nevertheless there was a significant correlation between day 2 and 3 month values (P less than 0.0005). Serum triglyceride levels on day 2 were influenced by glucose tolerance and were significantly lower than the 3 month values in patients with normal glucose tolerance but not in patients with abnormal glucose tolerance. However there with a significant correlation between day 2 triglyceride values in patients with both normal and abnormal glucose tolerance. These results suggest that serum cholesterol measured on admission after acute myocardial infarction may be reliably used to represent basal values in both men and women irrespective of glucose tolerance. Although cholesterol and triglycerides measured on day 2 vary with either the gender or glucose tolerance of the patients, these values are still a useful guide to the patients' basal lipid state.
对159例印度急性心肌梗死患者（134例男性）在住院期间（第1天和第2天）及3个月后测量了血清总胆固醇和甘油三酯，以评估急性心肌梗死后不久测得的血脂水平是否代表基础值。还根据患者的性别和糖耐量比较了早期和3个月时的血脂水平。无论糖耐量如何，男性（6.09±0.10 vs 6.18±0.09 mmol/L）和女性（6.75±0.30 vs 6.44±0.22 mmol/L）入院时（第1天）的平均总胆固醇水平与3个月时的值相当。在整个组中，第2天的胆固醇水平显著低于入院时和3个月时的值。然而，第2天和3个月时的值之间存在显著相关性（P＜0.0005）。第2天的血清甘油三酯水平受糖耐量影响，糖耐量正常的患者中该水平显著低于3个月时的值，但糖耐量异常的患者中并非如此。然而，糖耐量正常和异常的患者中第2天甘油三酯值之间存在显著相关性。这些结果表明，急性心肌梗死后入院时测得的血清胆固醇可可靠地用于代表男性和女性的基础值，无论糖耐量如何。虽然第2天测得的胆固醇和甘油三酯随患者的性别或糖耐量而变化，但这些值仍是患者基础血脂状态的有用指导。
