Sewdarsen M, Jialal I, Vythilingum S
S Afr Med J. 1983 Feb 12;63(7):238-40.
Glucose tolerance and lipid levels in a random sample of 103 Indian patients (96 males and 7 females) with coronary artery disease (CAD) aged between 20 and 55 years were compared with those in a healthy Indian control group matched as regards age and sex. Previous episodes of myocardial infarction were taken as evidence of CAD. Of the patients 44% were overweight. Glucose tolerance was abnormal in 55% of the patients. Both cholesterol and triglyceride values in the patients with CAD were significantly higher than those in the control group. Serum cholesterol levels were over 6,5 mmol/l in 62% of the patients with CAD and serum triglyceride levels were over 2,0 mmol/l in .53%. Males with CAD tended to have lower plasma high-density lipoprotein (HDL) cholesterol levels than the control group (P less than 0,01). There was a significant negative correlation between body mass index and HDL cholesterol, and no correlation was demonstrated between body mass index and total cholesterol or triglyceride levels. Furthermore, when the patients were sub-grouped according to their glucose tolerances it was found that only the triglyceride levels were significantly different (values were higher in those with abnormal glucose tolerance). Our data suggest that abnormal glucose tolerance and lipid aberrations are significant risk factors in Indian patients with CAD.
将103名年龄在20至55岁之间患有冠状动脉疾病（CAD）的印度患者（96名男性和7名女性）的随机样本的葡萄糖耐量和血脂水平，与年龄和性别相匹配的健康印度对照组进行了比较。既往心肌梗死发作被视为CAD的证据。44%的患者超重。55%的患者葡萄糖耐量异常。CAD患者的胆固醇和甘油三酯值均显著高于对照组。62%的CAD患者血清胆固醇水平超过6.5 mmol/l，53%的患者血清甘油三酯水平超过2.0 mmol/l。CAD男性患者的血浆高密度脂蛋白（HDL）胆固醇水平往往低于对照组（P小于0.01）。体重指数与HDL胆固醇之间存在显著负相关，体重指数与总胆固醇或甘油三酯水平之间未显示相关性。此外，当根据患者的葡萄糖耐量进行亚组划分时，发现只有甘油三酯水平存在显著差异（葡萄糖耐量异常者的值更高）。我们的数据表明，葡萄糖耐量异常和血脂异常是印度CAD患者的重要危险因素。
