Savill J S, Barrie R, Ghosh S, Muhlemann M, Dawson P, Pusey C D
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Postgrad Med J. 1988 May;64(751):392-4. doi: 10.1136/pgmj.64.751.392.
A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.
一名46岁患有活动性系统性红斑狼疮的白人女性，在静脉注射非离子型造影剂碘帕醇进行静脉尿路造影8小时后出现皮疹。随后发展为伴有多形红斑的严重史蒂文斯-约翰逊综合征、肝内胆汁淤积、肺部浸润和急性肾衰竭，最终导致死亡。尽管非离子型造影剂通常比传统离子型造影剂毒性小，但在免疫疾病患者中使用可能具有危险性。
