系统性红斑狼疮患者使用碘帕醇进行尿路造影后发生致命性史蒂文斯-约翰逊综合征。
Fatal Stevens-Johnson syndrome following urography with iopamidol in systemic lupus erythematosus.
作者信息
Savill J S, Barrie R, Ghosh S, Muhlemann M, Dawson P, Pusey C D
机构信息
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
出版信息
Postgrad Med J. 1988 May;64(751):392-4. doi: 10.1136/pgmj.64.751.392.
A 46 year old white woman with active systemic lupus erythematosus developed a skin rash 8 hours after intravenous urography with the non-ionic contrast medium iopamidol. Severe Stevens-Johnson syndrome with erythema multiforme, intrahepatic cholestasis, pulmonary infiltrates and acute renal failure ensued, leading to her death. Although non-ionic contrast media are generally less toxic than traditional ionic agents, their use in patients with immunological disease may be hazardous.
一名46岁患有活动性系统性红斑狼疮的白人女性，在静脉注射非离子型造影剂碘帕醇进行静脉尿路造影8小时后出现皮疹。随后发展为伴有多形红斑的严重史蒂文斯-约翰逊综合征、肝内胆汁淤积、肺部浸润和急性肾衰竭，最终导致死亡。尽管非离子型造影剂通常比传统离子型造影剂毒性小，但在免疫疾病患者中使用可能具有危险性。
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