补体和造影剂反应剂。

Complement and contrast material reactors.

作者信息

Lasser E C, Lang J H, Lyon S G, Hamblin A E

出版信息

J Allergy Clin Immunol. 1979 Aug;64(2):105-12. doi: 10.1016/0091-6749(79)90043-5.

Abstract

Patients showing systemic reactions to intravascular contrast media and patients receiving contrast media without reaction have significantly different mean values (p is less than 0.05) for functionally determined serum C1-esterase inhibitor (C1 INH) and total hemolytic complement (CH50). The lower concentration of these components in reactors appears in baseline serum samples (as well as after injection), and suggests that many anaphylactoid reactions to contrast media are conditioned by earlier complement consumption, and result directly from contrast-induced activation of complement, and other activation system components in the presence of inhibitor depression.

摘要

对血管内造影剂出现全身反应的患者和未出现反应的接受造影剂的患者，其功能测定的血清C1酯酶抑制剂（C1 INH）和总溶血补体（CH50）的平均值有显著差异（p小于0.05）。这些成分在有反应者中的较低浓度出现在基线血清样本中（以及注射后），这表明许多对造影剂的类过敏反应是由早期补体消耗所决定的，并且直接源于造影剂在抑制剂降低的情况下诱导补体及其他激活系统成分的激活。