Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
School of Epidemiology, Public Health, and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada.
Child Psychiatry Hum Dev. 2020 Jun;51(3):461-470. doi: 10.1007/s10578-020-00957-y.
Maternal thyroid problems during pregnancy have been linked to neurocognitive impairments in children. While studies suggest that disorders of maternal thyroid function during pregnancy are associated with symptoms of mental health problems in children, little is known about the risk of clinically significant psychiatric disorders in adolescence. A sample of 2451 Canadian adolescents enrolled in the Ontario Child Health Study completed the Mini International Neuropsychiatric Interview for Children and Adolescents at 12-17 years of age. Their mothers self-reported thyroid problems during pregnancy. Gestational thyroid problems were associated with offspring oppositional defiant disorder (ODD; OR 3.73; 95% CI 1.69-8.24), conduct disorder (CD; OR 12.95; 95% CI 5.12-32.75), and social anxiety disorder (SAD; OR 6.25; 95% CI 2.53-15.47). Neither sex nor gestational age moderated associations between prenatal thyroid dysfunction and the majority of outcomes. School performance mediated 8% of the association between thyroid problems and SAD, 21% for CD and 53% for ODD.
母亲在怀孕期间的甲状腺问题与儿童的神经认知障碍有关。虽然研究表明，怀孕期间母体甲状腺功能障碍与儿童心理健康问题的症状有关，但对于青春期临床显著精神障碍的风险知之甚少。在安大略省儿童健康研究中，2451 名加拿大青少年完成了 12-17 岁的儿童和青少年迷你国际神经精神访谈。他们的母亲在怀孕期间自我报告有甲状腺问题。妊娠甲状腺问题与子女对立违抗性障碍（ODD；OR3.73；95%CI1.69-8.24）、品行障碍（CD；OR12.95；95%CI5.12-32.75）和社交焦虑障碍（SAD；OR6.25；95%CI2.53-15.47）有关。性别和胎龄均不能调节产前甲状腺功能障碍与大多数结果之间的关系。学业成绩在甲状腺问题与 SAD 之间的关联中占 8%，在 CD 中占 21%，在 ODD 中占 53%。
