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Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.

作者信息

Li Yaqi, Li Jian, Wang Renjie, Zhang Long, Fu Guoxiang, Wang Xueying, Wang Yebin, Fang Chuantao, Zhang Dandan, Du Duo, Ma Xiaoji, Pan Mengxue, Guo Qiang, Xu Xiaoya, Hu Xiang, Zhou Yi, Mo Shaobo, Wang Huijun, Gao Jianjun, Huang Shenglin, Liu Yun, Cai Sanjun, Hua Guoqiang, Peng Junjie, Yu Fa-Xing

机构信息

Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

出版信息

Protein Cell. 2020 Apr;11(4):292-298. doi: 10.1007/s13238-020-00691-0.

DOI:10.1007/s13238-020-00691-0
PMID:32008206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7093338/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2730/7093631/772df3b2a794/13238_2020_691_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2730/7093631/7679b429322d/13238_2020_691_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2730/7093631/772df3b2a794/13238_2020_691_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2730/7093631/7679b429322d/13238_2020_691_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2730/7093631/772df3b2a794/13238_2020_691_Fig2a_HTML.jpg

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本文引用的文献

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Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma.印戒细胞结直肠癌：结直肠腺癌罕见亚群的基因组见解。
Br J Cancer. 2019 Sep;121(6):505-510. doi: 10.1038/s41416-019-0548-9. Epub 2019 Aug 13.
2
Molecular Characterization of Colorectal Signet-Ring Cell Carcinoma Using Whole-Exome and RNA Sequencing.利用全外显子组测序和RNA测序对结直肠癌印戒细胞癌进行分子特征分析。
Transl Oncol. 2018 Aug;11(4):836-844. doi: 10.1016/j.tranon.2018.04.007. Epub 2018 May 7.
3
Oncogenic Signaling Pathways in The Cancer Genome Atlas.
遗传性 KDM6A 促进肿瘤免疫逃逸并加剧结直肠印戒细胞癌的预后。
Oncogene. 2024 Jun;43(23):1757-1768. doi: 10.1038/s41388-024-03029-w. Epub 2024 Apr 15.
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Case Report: Systemic treatment for breast and vulvar metastases from resected rectal signet ring cell carcinoma.病例报告：经手术切除的直肠印戒细胞癌发生乳腺及外阴转移的全身治疗
Front Oncol. 2023 Jul 6;13:1213888. doi: 10.3389/fonc.2023.1213888. eCollection 2023.
5
Blocking the Wnt/β‑catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review).阻断 Wnt/β-连环蛋白信号通路治疗结直肠癌：改善现有疗法的策略（综述）。
Int J Oncol. 2023 Feb;62(2). doi: 10.3892/ijo.2022.5472. Epub 2022 Dec 29.
6
The emerging era of personalized medicine in advanced colorectal cancer.晚期结直肠癌个体化医学的崭新时代。
J Gastroenterol Hepatol. 2022 Aug;37(8):1411-1425. doi: 10.1111/jgh.15937. Epub 2022 Jul 20.
7
Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer.肠道菌群失调和肠道屏障功能障碍：早发性结直肠癌的潜在解释。
Front Cell Infect Microbiol. 2021 Dec 13;11:744606. doi: 10.3389/fcimb.2021.744606. eCollection 2021.
8
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.结直肠印戒细胞癌的临床病理和分子特征：综述。
Pathol Oncol Res. 2021 Jul 26;27:1609859. doi: 10.3389/pore.2021.1609859. eCollection 2021.
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RNF43 is frequently mutated in colorectal and endometrial cancers.RNF43在结直肠癌和子宫内膜癌中经常发生突变。
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Prognostic significance and molecular features of signet-ring cell and mucinous components in colorectal carcinoma.结直肠癌中印戒细胞和黏液成分的预后意义及分子特征
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Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis.黏液性和印戒细胞结直肠癌在肿瘤生物学和预后方面与经典腺癌不同。
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Comprehensive molecular characterization of human colon and rectal cancer.全面的人类结肠和直肠癌分子特征分析。
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