Zhang Q, Wang Y, Lin X T, Xu F F, Hou Z Y, Li Z R, Yu Q W, Wang X M, Liu S W, Li R C, Zhang Z H
Department of Medical Imaging, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Research Center for Sectional and Imaging Anatomy, Shandong University Cheeloo College of Medicine, Jinan 250012, China.
Zhonghua Yi Xue Za Zhi. 2020 Jan 21;100(3):182-186. doi: 10.3760/cma.j.issn.0376-2491.2020.03.005.
To analyze morphological changes in central sulcus of the cerebral cortex in children with complete growth hormone deficiency (CGHD). Patients attending the Shandong Provincial Hospital who were diagnosed with CGHD or idiopathic short stature were recruited from January 2015 to January 2019. Thirty children with CGHD (18 males and 12 females, 5 to 14 years old) and 30 children with idiopathic short stature (22 males and 8 females, 5 to 14 years old) were included. Measurements of the central sulcus, including the average width, maximum depth, average depth, top length, bottom length and depth position-based profiles (DPP), were obtained using Brain VISA software. The significant differences between groups were statistically analyzed. The average width of bilateral central sulci in children with CGHD (left: (2.26±0.41) mm; right: (2.19±0.34) mm) were significantly higher than those in children with idiopathic short stature (left: (2.10±0.27) mm; right: (2.02±0.18) mm) (<0.05) ; The maximum depth of the left central sulcus ((19.67±1.29) mm) and the average depth of the right central sulcus ((14.18±1.41) mm) were significantly lower than those in children with idiopathic short stature (left maximum depth: (20.69±1.43) mm; right average depth: (14.92±1.21) mm) (<0.05) . Children with CGHD had significantly lower DPP at the middle part of the left central sulcus (sites: 46-54) and the inferior part of the right central sulcus(sites: 91-98). There are significant morphological changes of the central sulcus in children with CGHD, which may represent the structural basis of their relatively slower development in motor, cognitive and linguistic functional performance.
分析完全性生长激素缺乏症（CGHD）患儿大脑皮质中央沟的形态学变化。选取2015年1月至2019年1月在山东省立医院就诊的诊断为CGHD或特发性矮小症的患者。纳入30例CGHD患儿（男18例，女12例，5至14岁）和30例特发性矮小症患儿（男22例，女8例，5至14岁）。使用Brain VISA软件测量中央沟，包括平均宽度、最大深度、平均深度、顶部长度、底部长度和基于深度位置的轮廓（DPP）。对组间差异进行统计学分析。CGHD患儿双侧中央沟的平均宽度（左侧：(2.26±0.41)mm；右侧：(2.19±0.34)mm）显著高于特发性矮小症患儿（左侧：(2.10±0.27)mm；右侧：(2.02±0.18)mm）（<0.05）；左侧中央沟的最大深度（(19.67±1.29)mm）和右侧中央沟的平均深度（(14.18±1.41)mm）显著低于特发性矮小症患儿（左侧最大深度：(20.69±1.43)mm；右侧平均深度：(14.92±1.21)mm）（<0.05）。CGHD患儿左侧中央沟中部（位点：46 - 54）和右侧中央沟下部（位点：91 - 98）的DPP显著更低。CGHD患儿中央沟存在显著的形态学变化，这可能代表了他们在运动、认知和语言功能表现方面发育相对较慢的结构基础。
