胎盘健康的社会决定因素与婴儿未来的疾病风险。
Social Determinants of Placental Health and Future Disease Risks for Babies.
机构信息
Moore Institute, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA; Center for Developmental Health, Knight Cardiovascular Institute, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA; Department of Obstetrics and Gynecology, Oregon Health & Science University, 3181 SW Sam Jackson Road, Portland, OR 97239, USA; Bob and Charlee Moore Institute for Nutrition & Wellness, School of Medicine, Oregon Health & Science University, 3030 SW Moody Avenue, MDYMI, Portland, OR 97239, USA.
School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
出版信息
Obstet Gynecol Clin North Am. 2020 Mar;47(1):1-15. doi: 10.1016/j.ogc.2019.11.002.
Birthweight is a well-known predictor of adult-onset chronic disease. The placenta plays a necessary role in regulating fetal growth and determining birth size. Maternal stressors that affect placental function and prenatal growth include maternal overnutrition and undernutrition, toxic social stress, and exposure to toxic chemicals. These stressors lead to increased vulnerability to disease within any population. This vulnerability arises from placental and fetal exposure to stressors during fetal life. The biological drivers linking various social determinants of health to compromised placental function and fetal development have been little studied.
出生体重是成年后慢性疾病的一个已知预测因子。胎盘在调节胎儿生长和决定出生体重方面起着必要的作用。影响胎盘功能和胎儿生长的母体应激源包括母体营养过剩和营养不良、有毒的社会压力以及接触有毒化学物质。这些应激源会导致任何人群中疾病易感性的增加。这种易感性源于胎儿期胎盘和胎儿暴露于应激源。将各种健康社会决定因素与受损的胎盘功能和胎儿发育联系起来的生物学驱动因素研究甚少。
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