Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli 8, Rome 00168, Italy.
Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, L.go Agostino Gemelli 8, Rome 00168, Italy.
Psychiatr Clin North Am. 2020 Mar;43(1):127-137. doi: 10.1016/j.psc.2019.10.012. Epub 2019 Dec 5.
Mixed affective states occur in approximately 40% of patients with mood disorders and are burdened with a significant rate of comorbidities, including addictive disorders (AD). The co-occurrence of mixed features and AD represents a challenge for clinicians because the reciprocal, negative influence of these conditions leads to a worse course of illness, treatment resistance, unfavorable outcome, and higher suicide risk. This article discusses clinical presentation, possible common pathogenetic pathways, and treatment options. Further investigations are required to clarify the determinants and the implications of this co-occurrence, and to detect suitable approaches in clinical management.
混合性情感状态发生于约 40%的心境障碍患者中，且常与多种共病相关，包括物质使用障碍（SUD）。混合特征与 SUD 的共病是临床医生面临的挑战，因为这些情况的相互影响、负面作用导致疾病病程更差、治疗抵抗、预后不良和自杀风险增加。本文讨论了混合性情感状态的临床表现、可能的共同发病机制和治疗选择。需要进一步的研究来阐明这种共病的决定因素和影响，并在临床管理中发现合适的方法。
