Department of Dermatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine.
Department of Dermatology, Karamay People's Hospital.
Jpn J Infect Dis. 2020 May 22;73(3):226-230. doi: 10.7883/yoken.JJID.2019.280. Epub 2020 Jan 31.
Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus that causes chickenpox and zoster. Considering that VZV is a relatively and genetically stable virus, its global surveillance clades provide essential information for VZV evolution, immigration, and importation of different viral strains and recombination events. Eighty-eight VZV isolates from China (Shanghai and Urumqi) were genotyped using a scattered single-nucleotide polymorphism method in this prospective study. Our results were based on sequencing the open reading frames 1, 6, 12, 16, 17, 21, 22, 35, 37, 38, 50, 54, 55, 56, 60, and 66. We found that the majority of these 88 strains (81.8%) belonged to Clade 2 with significantly high homogeneity from Shanghai. However, in the Urumqi area, some strains were grouped to Clade 5, and some could not be attributed to any of the established VZV clades, although the majority of Urumqi strains belonged to Clade 2. Our results illustrated that due to geographical location, VZV could undergo genetic recombination, suggesting that VZV diversity is more complicated in certain areas and geographical separation contributes to VZV complexity.
水痘带状疱疹病毒（VZV）是一种普遍存在的人类疱疹病毒，可引起水痘和带状疱疹。鉴于 VZV 是一种相对稳定的病毒，其全球监测进化枝为 VZV 的进化、移民以及不同病毒株和重组事件的输入提供了重要信息。在这项前瞻性研究中，我们使用分散的单核苷酸多态性方法对来自中国（上海和乌鲁木齐）的 88 株 VZV 分离株进行了基因分型。我们的结果是基于对开放阅读框 1、6、12、16、17、21、22、35、37、38、50、54、55、56、60 和 66 的测序。我们发现，这些 88 株中的大多数（81.8%）属于 2 进化枝，与上海的高度同源性。然而，在乌鲁木齐地区，一些菌株被归类为 5 进化枝，而有些菌株则不能归入任何已建立的 VZV 进化枝，尽管大多数乌鲁木齐菌株属于 2 进化枝。我们的结果表明，由于地理位置的原因，VZV 可能会发生基因重组，这表明在某些地区，VZV 的多样性更为复杂，地理隔离有助于 VZV 的复杂性。
