IMIT, Interfakultäres Institut für Mikrobiologie und Infektionsmedizin University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
FEMS Microbiol Lett. 2020 Jan 1;367(2). doi: 10.1093/femsle/fnaa013.
Many Escherichia coli phages have been sequenced, but in most cases their sequences alone do not suffice to predict their host specificity. Analysis of phage resistant E. coli K-12 mutants have uncovered a certain set of outer membrane proteins and polysaccharides as receptors. In this review, a compilation of E. coli K12 phage receptors is provided and their functional characterization, often driven by studies on phage resistant mutants, is discussed in the historical context. While great progress has been made in this field thus far, several proteins in the outer membrane still await characterization as phage receptors.
许多大肠杆菌噬菌体已经被测序,但在大多数情况下,仅凭它们的序列不足以预测其宿主特异性。对噬菌体抗性大肠杆菌 K-12 突变体的分析揭示了一组特定的外膜蛋白和多糖作为受体。在这篇综述中,提供了大肠杆菌 K12 噬菌体受体的汇编,并在历史背景下讨论了它们的功能特征,这些特征通常是由对噬菌体抗性突变体的研究驱动的。尽管到目前为止,该领域已经取得了很大的进展,但外膜中的几个蛋白质仍有待鉴定为噬菌体受体。