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来自过敏和非过敏个体的原代鼻上皮细胞具有可比的屏障功能。

Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function.

作者信息

Waltl Eva E, Stanek Victoria, Mueller Christian A, Kiss Renata, Eckl-Dorna Julia, Valenta Rudolf, Niederberger Verena

机构信息

Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.

Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

出版信息

Allergy Asthma Immunol Res. 2020 Mar;12(2):364-370. doi: 10.4168/aair.2020.12.2.364.

DOI:10.4168/aair.2020.12.2.364
PMID:32009328
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6997283/
Abstract

Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that primary nasal epithelial cells from allergic and non-allergic individuals showed comparable barrier function and secretion of cytokines.

摘要

先前的报告表明，过敏性患者的体外培养的原代鼻上皮细胞与非过敏性个体的原代鼻上皮细胞相比，屏障功能确实降低。相比之下，我们发现过敏性和非过敏性个体的原代鼻上皮细胞表现出相当的屏障功能和细胞因子分泌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b15/6997283/98090a98c9a1/aair-12-364-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b15/6997283/f90253c58e72/aair-12-364-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b15/6997283/98090a98c9a1/aair-12-364-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b15/6997283/f90253c58e72/aair-12-364-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b15/6997283/98090a98c9a1/aair-12-364-g002.jpg

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本文引用的文献

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Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function.倍他米松可预防人鼻病毒和香烟烟雾引起的呼吸道上皮屏障功能丧失。
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Histamine and T helper cytokine-driven epithelial barrier dysfunction in allergic rhinitis.变应性鼻炎中组胺和辅助性 T 细胞细胞因子驱动的上皮屏障功能障碍。
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Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression.屋尘螨诱导的变应性鼻炎患者的屏障功能受损与闭合蛋白和闭合小带-1 表达减少有关。
J Allergy Clin Immunol. 2016 Apr;137(4):1043-1053.e5. doi: 10.1016/j.jaci.2015.10.050. Epub 2016 Feb 2.
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The sentinel role of the airway epithelium in asthma pathogenesis.气道上皮在哮喘发病机制中的哨点作用。
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Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses.经鼻应用重组变应原Bet v 1（rBet v 1）或含非IgE反应性T细胞表位的rBet v 1片段，对全身变应原特异性抗体反应有不同影响。
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Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells.胸腺基质淋巴细胞生成素增强人鼻腔上皮细胞的紧密连接屏障功能。
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