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Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses.

作者信息

Egger Cornelia, Horak Friedrich, Vrtala Susanne, Valenta Rudolf, Niederberger Verena

出版信息

J Allergy Clin Immunol. 2010 Dec;126(6):1312-5.e4. doi: 10.1016/j.jaci.2010.06.008. Epub 2010 Jul 31.

DOI:10.1016/j.jaci.2010.06.008
PMID:20673979
Abstract
摘要

相似文献

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Nasal application of rBet v 1 or non-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses.经鼻应用重组变应原Bet v 1(rBet v 1)或含非IgE反应性T细胞表位的rBet v 1片段,对全身变应原特异性抗体反应有不同影响。
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2
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A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype.一种由 PreS 融合的 Bet v 1 肽组成的非变应原性桦树花粉过敏疫苗,其作用是阻断针对 IgE 表位的 IgG 并将免疫应答转向耐受原性和 Th1 表型。
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IgE and allergen-specific immunotherapy-induced IgG recognize similar epitopes of Bet v 1, the major allergen of birch pollen.IgE 和变应原特异性免疫治疗诱导的 IgG 识别桦树花粉主要过敏原 Bet v 1 的相似表位。
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Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.过敏原组多肽微阵列可用于过敏原特异性免疫治疗中的表位剖析。
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Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy.一种低变应原性重组Bet v 1变体作为变应原特异性免疫疗法候选物的特性分析。
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Frequent occurrence of T cell-mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments.用低变应原性rBet v 1片段进行特应性皮炎斑贴试验揭示T细胞介导的迟发性反应频繁发生。
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A B Cell Epitope Peptide Derived from the Major Grass Pollen Allergen Phl p 1 Boosts Allergen-Specific Secondary Antibody Responses without Allergen-Specific T Cell Help.一种源自主要草花粉过敏原Phl p 1的B细胞表位肽可增强过敏原特异性二次抗体反应,且无需过敏原特异性T细胞辅助。
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