Noto Yu-Ichi, Kondo Masaki, Tsuji Yukiko, Matsushima Shigenori, Mizuno Toshiki, Tokuda Takahiko, Nakagawa Masanori
Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Front Neurol. 2020 Jan 17;10:1386. doi: 10.3389/fneur.2019.01386. eCollection 2019.
The accumulation of multiple-protein aggregates within muscle fibers is a pathological hallmark of sporadic inclusion body myositis (s-IBM) with the presence of inclusion bodies. Amyloid-beta is one of the accumulated proteins in s-IBM. The aim of this study was to elucidate the utility of Pittsburgh compound B-positron emission tomography (PIB-PET) for diagnosing s-IBM. Nine patients with s-IBM and four patients with idiopathic inflammatory myopathy (IIM) were included. Patients underwent PIB-PET of body muscles. Standardized uptake values (SUVs) were measured in 16 muscles. A comparison of SUVs was made between s-IBM and IIM groups. The correlation between PIB-PET and clinical parameters was analyzed. The mean SUV of all muscles in s-IBM patients was higher than in IIM patients (0.32 vs. 0.25, respectively; = 0.031). Subgroup analysis identified a clear difference in SUVs of the forearm and lower-leg muscle groups ( = 0.021 and = 0.045, respectively). There was no correlation between SUVs and clinical parameters in s-IBM patients. Muscle PIB-PET may help to make a diagnosis of s-IBM.
肌肉纤维内多种蛋白质聚集体的积累是散发性包涵体肌炎（s-IBM）伴有包涵体存在的病理标志。β-淀粉样蛋白是s-IBM中积累的蛋白质之一。本研究的目的是阐明匹兹堡化合物B正电子发射断层扫描（PIB-PET）在诊断s-IBM中的效用。纳入了9例s-IBM患者和4例特发性炎性肌病（IIM）患者。患者接受了全身肌肉的PIB-PET检查。在16块肌肉中测量标准化摄取值（SUV）。对s-IBM组和IIM组的SUV进行了比较。分析了PIB-PET与临床参数之间的相关性。s-IBM患者所有肌肉的平均SUV高于IIM患者（分别为0.32和0.25；P = 0.031）。亚组分析发现前臂和小腿肌肉组的SUV存在明显差异（分别为P = 0.021和P = 0.045）。s-IBM患者的SUV与临床参数之间无相关性。肌肉PIB-PET可能有助于s-IBM的诊断。
