包涵体肌炎中[11C]PIB-PET水平升高表明存在β淀粉样蛋白沉积。 - Suppr

Increased [11C]PIB-PET levels in inclusion body myositis are indicative of amyloid beta deposition.

作者信息

Maetzler Walter, Reimold Matthias, Schittenhelm Jens, Vorgerd Matthias, Bornemann Antje, Kötter Ina, Pfannenberg Christina, Reischl Gerald, Schöls Ludger

出版信息

J Neurol Neurosurg Psychiatry. 2011 Sep;82(9):1060-2. doi: 10.1136/jnnp.2009.197640. Epub 2010 Aug 22.

DOI:10.1136/jnnp.2009.197640

PMID:20732867

Abstract

摘要

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Increased [11C]PIB-PET levels in inclusion body myositis are indicative of amyloid beta deposition.包涵体肌炎中[11C]PIB-PET水平升高表明存在β淀粉样蛋白沉积。

J Neurol Neurosurg Psychiatry. 2011 Sep;82(9):1060-2. doi: 10.1136/jnnp.2009.197640. Epub 2010 Aug 22.

C-PIB PET of inclusion body myositis: Molecular imaging of amyloid beta expression improving imaging-pathology correlations.包涵体肌炎的C-PIB正电子发射断层扫描：淀粉样β蛋白表达的分子成像改善影像与病理的相关性

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Dysferlin is a newly identified binding partner of AβPP and it co-aggregates with amyloid-β42 within sporadic inclusion-body myositis (s-IBM) muscle fibers.dysferlin是一种新发现的淀粉样前体蛋白（AβPP）结合伴侣，它与散发性包涵体肌炎（s-IBM）肌纤维中的β淀粉样蛋白42（amyloid-β42）共同聚集。

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Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.用于阿尔茨海默病诊断的β淀粉样蛋白PET显像剂2-(4-N-[11C]甲基氨基苯基)-6-羟基苯并噻唑([11C]PIB)的合成优化

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Quantification of β-Amyloidosis and rCBF with Dedicated PET, 7 T MR Imaging, and High-Resolution Microscopic MR Imaging at 16.4 T in APP23 Mice.在APP23小鼠中，使用专用正电子发射断层扫描（PET）、7T磁共振成像（MRI）以及16.4T高分辨率显微MRI对β淀粉样变性和局部脑血流（rCBF）进行定量分析。

J Nucl Med. 2015 Oct;56(10):1593-9. doi: 10.2967/jnumed.115.159350. Epub 2015 Aug 6.

Unfolding story of inclusion-body myositis and myopathies: role of misfolded proteins, amyloid-beta, cholesterol, and aging.

J Child Neurol. 2003 Mar;18(3):185-90. doi: 10.1177/08830738030180030401.

Standardized Expression of 18F-NAV4694 and 11C-PiB β-Amyloid PET Results with the Centiloid Scale.使用百分等级量表对18F-NAV4694和11C-PiBβ淀粉样蛋白PET结果进行标准化表达。

J Nucl Med. 2016 Aug;57(8):1233-7. doi: 10.2967/jnumed.115.171595. Epub 2016 Feb 16.

Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid.正电子发射断层扫描放射性药物在脑β淀粉样蛋白成像中的应用。

Semin Nucl Med. 2011 Jul;41(4):283-99. doi: 10.1053/j.semnuclmed.2011.02.005.

Nitric oxide stress in sporadic inclusion body myositis muscle fibres: inhibition of inducible nitric oxide synthase prevents interleukin-1β-induced accumulation of β-amyloid and cell death.散发性包涵体肌炎肌纤维中的一氧化氮应激：抑制诱导型一氧化氮合酶可防止白细胞介素-1β诱导的β-淀粉样蛋白积累和细胞死亡。

Brain. 2012 Apr;135(Pt 4):1102-14. doi: 10.1093/brain/aws046. Epub 2012 Mar 21.

Provision of an explanation for the inefficacy of immunotherapy in sporadic inclusion body myositis: quantitative assessment of inflammation and β-amyloid in the muscle.散发性包涵体肌炎中免疫治疗无效的原因解释：肌肉炎症和β-淀粉样蛋白的定量评估

Arthritis Rheum. 2012 Dec;64(12):4094-103. doi: 10.1002/art.37692.

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Imaging With PET/CT of Diffuse CD8 T-Cell Infiltration of Skeletal Muscle in Patients With Inclusion Body Myositis.PET/CT 对包涵体肌炎患者骨骼肌弥漫性 CD8+T 细胞浸润的影像学研究。

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Front Neurol. 2020 Jan 17;10:1386. doi: 10.3389/fneur.2019.01386. eCollection 2019.

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives.遗传性和获得性肌病定量成像的进展：临床应用与展望

Front Neurol. 2019 Feb 11;10:78. doi: 10.3389/fneur.2019.00078. eCollection 2019.

[18F]Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis.[18F]氟代脱氧葡萄糖正电子发射断层扫描：在包涵体肌炎中识别肌肉淀粉样变性并与多发性肌炎相区别。

Ann Rheum Dis. 2019 May;78(5):657-662. doi: 10.1136/annrheumdis-2018-214644. Epub 2019 Feb 13.

Inclusion body myositis.包涵体肌炎。

Neurol Clin. 2014 Aug;32(3):629-46, vii. doi: 10.1016/j.ncl.2014.04.001. Epub 2014 Jun 6.

Update in inclusion body myositis.包涵体肌炎的最新进展。

Curr Opin Rheumatol. 2013 Nov;25(6):763-71. doi: 10.1097/01.bor.0000434671.77891.9a.

Inclusion body myositis.包涵体肌炎。

Curr Neurol Neurosci Rep. 2013 Jan;13(1):321. doi: 10.1007/s11910-012-0321-4.

Inclusion body myositis.包涵体肌炎。

Semin Neurol. 2012 Jul;32(3):237-45. doi: 10.1055/s-0032-1329197. Epub 2012 Nov 1.

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Increased [11C]PIB-PET levels in inclusion body myositis are indicative of amyloid beta deposition.

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