Flint Animal Cancer Center, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Front Immunol. 2020 Jan 17;10:2935. doi: 10.3389/fimmu.2019.02935. eCollection 2019.
While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies in pet dogs with cancer has been increasingly recognized by the research community. This review will therefore summarize key aspects of the dog cancer immunotherapy model and the role that these studies may play in the overall immunotherapy drug research effort. We will focus on cancer types and settings in which the dog model is most likely to impact clinical immuno-oncology research and drug development. Immunological reagent availability is discussed, along with some unique opportunities and challenges associated with the dog immunotherapy model. Overall it is hoped that this review will increase awareness of the dog cancer immunotherapy model and stimulate additional collaborative studies to benefit both man and man's best friend.
虽然啮齿动物癌症模型对于免疫疗法的早期概念验证和机制研究至关重要，但这些模型在预测新免疫疗法在人类中的最终有效性方面存在局限性。作为一种独特的自发、大型动物癌症模型，在患有癌症的宠物犬身上开展研究的价值已逐渐被研究界所认可。因此，本综述将总结犬癌症免疫疗法模型的关键方面，以及这些研究在整体免疫疗法药物研究工作中可能发挥的作用。我们将重点介绍犬模型最有可能对临床免疫肿瘤学研究和药物开发产生影响的癌症类型和环境。本文讨论了免疫试剂的可获得性，以及与犬免疫疗法模型相关的一些独特机遇和挑战。总的来说，我们希望这篇综述能够提高人们对犬癌症免疫疗法模型的认识，并激发更多的合作研究，造福人类和人类最好的朋友。
