Xi Lei
Department of Ophthalmology, Peking University International Hospital, Beijing 102206, P.R. China.
Division of Experimental Vitreoretinal Surgery, Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, D-72076 Tuebingen, Germany.
Exp Ther Med. 2020 Feb;19(2):1183-1188. doi: 10.3892/etm.2019.8338. Epub 2019 Dec 17.
The present study aimed to evaluate the changes of corneal higher-order aberrations (HOAs) after transepithelial photorefractive keratectomy (TransPRK) in patients with myopia. A total of 80 eyes of 80 patients with myopia with or without astigmatism were evaluated. Prior to and 1 year after the surgery, uncorrected and corrected distance visual acuity in logMAR were assessed. Wavefront aberrations on the anterior surface of the cornea, as well as the posterior and total cornea, were measured via Pentacam. The HOA of the anterior surface and total values of spherical and coma aberrations increased significantly (P<0.001). However, HOAs of the anterior surface, and posterior and total values of the trefoil were not significantly changed (P=0.442, 0.805 and 0.936, respectively). A significant correlation of the pre-operative mean spherical equivalent refraction (MSER), astigmatism and central corneal ablation depth (CCAD) with the changes in coma aberration (r=0.268, P=0.016; r=0.260, P=0.020; r=0.323, P=0.004, respectively) and HOA (r=0.554, P<0.001; r=0.312, P=0.005; r=0.583, P<0.001, respectively) of the anterior surface of the cornea was determined. Furthermore, a significant correlation of the pre-operative MSER and CCAD with the changes in spherical aberration of the anterior corneal surface (r=0.462, P<0.001; r=0.510, P<0.001, respectively) was obtained. In conclusion, TransPRK offers an effective option for improving visual function in patients with myopia. The anterior corneal HOA, as well as spherical and coma aberrations, were significantly increased post-operatively. The HOA of the posterior cornea was not significantly changed. The change in the trefoil aberration was significantly correlated with pre-operative astigmatism, but the pre- and post-operative values were not significantly different.
本研究旨在评估近视患者经上皮准分子激光角膜切削术（TransPRK）后角膜高阶像差（HOAs）的变化。共评估了80例近视患者（有或无散光）的80只眼。在手术前和手术后1年，评估logMAR视力的未矫正和矫正远视力。通过Pentacam测量角膜前表面以及后表面和全角膜的波前像差。角膜前表面的高阶像差以及球差和彗差的总值显著增加（P<0.001）。然而，角膜前表面的高阶像差以及三叶像差的后表面和总值没有显著变化（分别为P=0.442、0.805和0.936）。术前平均球镜等效屈光度（MSER）、散光和中央角膜切削深度（CCAD）与彗差变化（分别为r=0.268，P=0.016；r=0.260，P=0.020；r=0.323，P=0.004）和角膜前表面高阶像差（分别为r=0.554，P<0.001；r=0.312，P=0.005；r=0.583，P<0.001）之间存在显著相关性。此外，术前MSER和CCAD与角膜前表面球差变化之间存在显著相关性（分别为r=0.462，P<0.001；r=0.510，P<0.001）。总之，TransPRK为改善近视患者的视觉功能提供了一种有效的选择。术后角膜前表面高阶像差以及球差和彗差显著增加。角膜后表面的高阶像差没有显著变化。三叶像差的变化与术前散光显著相关，但术前和术后值没有显著差异。
