宫内生长受限的小于胎龄新生儿脐带血中的去酰基胃饥饿素和瘦素
DESACYLATED GHRELIN AND LEPTIN IN THE CORD BLOOD OF SMALL-FOR-GESTATIONAL-AGE NEWBORNS WITH INTRAUTERINE GROWTH RESTRICTION.
作者信息
Bucur-Grosu M L, Avasiloaiei A, Moscalu M, Dimitriu D C, Păduraru L, Stamatin M
机构信息
"Grigore T. Popa" University of Medicine and Pharmacy, Department of Mother and Child Health, Iasi, Romania.
"Cuza-Voda" Clinical Hospital of Obstetrics and Gynecology, Neonatal Intensive Care Unit, Iasi, Romania.
出版信息
Acta Endocrinol (Buchar). 2019 Jul-Sep;15(3):305-310. doi: 10.4183/aeb.2019.305.
CONTEXT
Ghrelin, in both its acylated and desacylated forms, and leptin can modulate fetal energy balance and development.
OBJECTIVE
The aim of our study is to assess desacylated ghrelin (DAG) and leptin values and influence on intrauterine and postnatal growth in infants with intrauterine growth restriction.
DESIGN SUBJECTS AND METHODS
We performed a prospective study on 39 infants recruited over five months, 20 appropriate - for - gestational - age (AGA) infants and 19 small-for-gestational-age (SGA) infants, in which we measured DAG and leptin in the umbilical cord blood and we compared their respective values between the two groups, along with auxological parameters at birth and at 10 months of postnatal age.
RESULTS
Our results show that both DAG and leptin have lower values in SGA infants and correlate with most of the anthropometrical parameters at birth. Both hormones correlate with weight at 10 months in SGA infants, but this correlation lacks in AGA infants. Whereas DAG in the cord blood can be considered a predictor for weight at 10 months (β=0.207, p=0.001), the same cannot be stated about leptin (β=0.078, p=0.195).
CONCLUSION
DAG and leptin are involved in both intrauterine and postnatal development, but the extent of their role is still to be determined.
背景
酰基化和去酰基化形式的胃饥饿素以及瘦素均可调节胎儿的能量平衡和发育。
目的
我们研究的目的是评估去酰基化胃饥饿素（DAG）和瘦素水平及其对宫内生长受限婴儿宫内和出生后生长的影响。
设计、研究对象与方法：我们进行了一项前瞻性研究，在五个月内招募了39名婴儿，其中20名适于胎龄（AGA）婴儿和19名小于胎龄（SGA）婴儿，我们测量了脐带血中的DAG和瘦素，并比较了两组之间它们各自的值，以及出生时和出生后10个月时的体格测量参数。
结果
我们的结果表明，SGA婴儿的DAG和瘦素水平均较低，且与出生时的大多数人体测量参数相关。两种激素均与SGA婴儿10个月时的体重相关，但AGA婴儿不存在这种相关性。虽然脐带血中的DAG可被视为10个月时体重的预测指标（β=0.207，p=0.001），但瘦素并非如此（β=0.078，p=0.195）。
结论
DAG和瘦素均参与宫内和出生后发育，但其作用程度仍有待确定。
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