Dardzińska Jolanta Anna, Małgorzewicz Sylwia, Kaska Łukasz, Proczko Monika, Stefaniak Tomasz, Stankiewicz Marta, Śledziński Zbigniew
Endokrynol Pol. 2014;65(5):377-81. doi: 10.5603/EP.2014.0052.
The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin's (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.
Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).
Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.
It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies.
两种形式的胃饥饿素在肥胖症中潜在的不同作用尚不明确，关于去酰基胃饥饿素（DAG）受进食调节的情况也知之甚少。我们旨在评估肥胖和非肥胖受试者进食混合餐前后酰基胃饥饿素（AG）和DAG的变化。
两组受试者在过夜禁食后以及食用标准300千卡混合餐（纽迪希亚公司的营养饮品）两小时后采集静脉血，用于检测血浆葡萄糖、AG和DAG。
肥胖个体的AG和DAG空腹均值均显著较低。另一方面，在非肥胖对照组中，餐后DAG均值未变，AG水平下降；而在肥胖个体中，混合餐后DAG均值降低，AG水平未变。
有必要区分胃饥饿素的去酰基化和酰基化形式，因为我们已表明肥胖和非肥胖个体餐后AG和DAG反应存在差异。针对AG和DAG之间比例变化进行干预是否会成为肥胖症治疗的成功策略仍是未来研究的课题。
