Van Anh Ton Nu, Hao Tran Kiem, Chi Nguyen Thi Diem, Son Nguyen Huu
Pediatric Department, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.
Pediatric Center, Hue Central Hospital, Hue, Vietnam.
Open Access Maced J Med Sci. 2019 Oct 13;7(21):3564-3567. doi: 10.3889/oamjms.2019.581. eCollection 2019 Nov 15.
The aim of the study was to investigate the role of umbilical cord blood lactate as early predictors of hypoxic ischemic encephalopathy in newborns with perinatal asphyxia and to evaluate their sensitivity and specificity for the early identification of hypoxic ischemic encephalopathy infants.
We performed a descriptive cross sectional study between April 2014 and April 2015 at Hue Central Hospital, Vietnam. 41 asphyxia newborns (Apgar score ≤ 7) were included in the study. Umbilical cord blood is sampled for lactate analysis.
Umbilical cord blood lactate levels were significantly higher among infants born with HIE (mean 8.72 ± 1.75, range 5.12 - 11.96) compared to that with asphyxic infants without HIE (mean 6.86 ± 1.33, range 4.74 - 10.30), p = 0.00. With the optimal cutoff point for umbilical cord blood lactate level of 8.12 mmol/l to susspected of HIE (area under the curve 0.799) had a sensitivity 73.7% (95% CI 48.8-90.9), specificity 86.4% (95% CI 65.1-97.1).
Umbilical cord blood lactate could be used as early predictors in diagnosis of hypoxic ischemic encephalopathy in newborns with asphyxia.
本研究旨在探讨脐血乳酸在围产期窒息新生儿缺氧缺血性脑病早期预测中的作用，并评估其对缺氧缺血性脑病患儿早期识别的敏感性和特异性。
2014年4月至2015年4月期间，我们在越南顺化中心医院进行了一项描述性横断面研究。41例窒息新生儿（阿氏评分≤7分）纳入本研究。采集脐血进行乳酸分析。
与无缺氧缺血性脑病的窒息新生儿相比，患缺氧缺血性脑病的新生儿脐血乳酸水平显著更高（平均值8.72±1.75，范围5.12 - 11.96），无缺氧缺血性脑病的窒息新生儿脐血乳酸水平平均值为6.86±1.33，范围4.74 - 10.30，p = 0.00。脐血乳酸水平的最佳截断点为8.12 mmol/l时，疑似缺氧缺血性脑病（曲线下面积0.799）的敏感性为73.7%（95%可信区间48.8 - 90.9），特异性为86.4%（95%可信区间65.1 - 97.1）。
脐血乳酸可作为窒息新生儿缺氧缺血性脑病诊断的早期预测指标。
