Kumazawa Toshihiko, Kotake Kunihiko, Nishimura Atsuhisa, Asai Noriyuki, Ugajin Tsukasa, Yokozeki Hiroo, Adachi Takahiro
Ichibiki Co., Ltd., Nagoya, Aichi 456-0018, Japan.
Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
Biosci Microbiota Food Health. 2020;39(1):1-9. doi: 10.12938/bmfh.19-012. Epub 2019 Sep 21.
Recently, we found a novel function of the lactic acid bacterium derived from miso, a fermented soy paste, that induces interleukin (IL)-22 production in B cells preferentially. IL-22 plays a critical role in barrier functions in the gut and skin. We further screened other bacteria species, namely, , , , , , , and , in addition to and found that some of them possessed robust IL-22-inducible function in B cells . This process resulted in the augmented expression of activation markers CD86 and CD69 on B and T cells, respectively. However, these observations were not correlated with IL-22 production. We isolated sc-09 from miso and determined it to be the best strain to induce robust IL-22 production in B cells. Furthermore, feeding sc-09 to mice augmented the barrier function of the skin regardless of gut microbiota.
最近，我们发现了一种源自味噌（一种发酵大豆酱）的乳酸菌的新功能，它能优先诱导B细胞产生白细胞介素（IL）-22。IL-22在肠道和皮肤的屏障功能中起关键作用。除了[具体菌种1]和[具体菌种2]外，我们还进一步筛选了其他菌种，即[其他菌种名称列举]，发现其中一些菌种在B细胞中具有强大的IL-22诱导功能。这一过程分别导致B细胞和T细胞上激活标志物CD86和CD69的表达增加。然而，这些观察结果与IL-22的产生并无关联。我们从味噌中分离出sc-09，并确定它是诱导B细胞产生强大IL-22的最佳菌株。此外，给小鼠喂食sc-09可增强皮肤的屏障功能，而与肠道微生物群无关。
