Park Hyung Jun, Joh Hee-Kyung, Choi Seulggie, Park Sang Min
Department of Family Medicine, SMG - SNU Boramae Medical Center, Seoul, Republic of Korea.
Department of Family Medicine, Seoul National University Health Service Center, Seoul, Republic of Korea.
Transl Lung Cancer Res. 2019 Dec;8(6):1073-1077. doi: 10.21037/tlcr.2019.11.01.
Previous studies have reported higher incidences of lung cancer among smokers diagnosed with diabetes than those without. Accordingly, this study investigated whether type 2 diabetes mellitus (T2DM) diagnosis alone can be associated with increased lung cancer incidences among never-smokers in the Korean population. Newly diagnosed never-smoking T2DM patients were identified from the nationwide longitudinal cohort of health examination data of South Korea (2002-2013). Cox proportional hazards regression model was employed to estimate the hazard ratios (HRs) and 95% confidence interval (CI) of lung cancer in the T2DM patient and abnormal fasting blood sugar (FBS) groups. T2DM (HR =0.91, 95% CI: 0.71 to 1.17) and abnormal FBS level are no significant association with lung cancer incidence based on the given HR. T2DM does not increase the risk of lung cancer among never-smokers. A large cohort study affirms minimal impact of T2DM on lung cancer development in the never-smoking Korean population.
以往研究报告称，被诊断患有糖尿病的吸烟者患肺癌的几率高于未患糖尿病的吸烟者。因此，本研究调查了仅2型糖尿病（T2DM）诊断是否与韩国非吸烟人群肺癌发病率增加有关。从韩国全国健康检查数据纵向队列（2002 - 2013年）中识别出新诊断的非吸烟T2DM患者。采用Cox比例风险回归模型估计T2DM患者和空腹血糖（FBS）异常组中肺癌的风险比（HRs）和95%置信区间（CI）。基于给定的HR，T2DM（HR = 0.91，95% CI：0.71至1.17）和FBS水平异常与肺癌发病率无显著关联。T2DM不会增加非吸烟者患肺癌的风险。一项大型队列研究证实，T2DM对韩国非吸烟人群肺癌发展的影响极小。
