Qiao Li, Ma Deliang, Lv Hui, Shi Ding, Fei Min, Chen Yu, Xie Fei, Wang Zhuoyan, Wang Ying, Liang Wanhua, Hu Peiying
Department of Oncology, Linyi Central Hospital, 17 Jian Kang Road, Linyi, 276400 Shandong China.
Health Promotion Center, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310006 Zhejiang China.
Diabetol Metab Syndr. 2020 Oct 28;12:95. doi: 10.1186/s13098-020-00598-0. eCollection 2020.
Metabolic syndrome (MetS) has been related to the pathogenesis of variety categories of cancers. This meta-analysis aimed to determine the association between MetS and the incidence of lung cancer.
Relevant cohort studies were identified by search of PubMed, Embase, and Cochrane's Library databases. Cochrane's Q test and I statistic were used to analyze the heterogeneity. Random-effect model which incorporates the potential heterogeneity was used for the meta-analysis.
Five cohort studies with 188,970 participants were included. A total of 1,295 lung cancer cases occurred during follow-up. Meta-analyses showed that neither MetS defined by the revised NCEP-ATP III criteria (hazard ratio [HR]: 0.94, 95% confidence interval [CI]: 0.84 to 1.05, p = 0.25; I = 0) nor the IDF criteria (HR: 0.82, 95% CI: 0.61 to 1.11, p = 0.20; I = 0) was associated with an affected risk of lung cancer. Subgroup analyses showed consistent results in women and in men, in studies performed in Asian and non-Asian countries, and in prospective and retrospective cohorts (p all > 0.05). Meta-analysis limited to studies with the adjustment of smoking status also showed similar results (HR: 0.91, 95% CI: 0.80 to 1.05, p = 0.21; I = 0). No publication bias was detected based on the Egger regression test (p = 0.32).
Current evidence from cohort studies does not support that MetS is an independent risk factor for the incidence of lung cancer.
代谢综合征（MetS）与多种癌症的发病机制相关。本荟萃分析旨在确定MetS与肺癌发病率之间的关联。
通过检索PubMed、Embase和Cochrane图书馆数据库来识别相关队列研究。采用Cochrane's Q检验和I统计量分析异质性。采用纳入潜在异质性的随机效应模型进行荟萃分析。
纳入了五项队列研究，共188,970名参与者。随访期间共发生1295例肺癌病例。荟萃分析表明，无论是根据修订的NCEP-ATP III标准定义的MetS（风险比[HR]：0.94，95%置信区间[CI]：0.84至1.05，p = 0.25；I = 0）还是国际糖尿病联盟（IDF）标准（HR：0.82，95% CI：0.61至1.11，p = 0.20；I = 0），均与肺癌患病风险无关。亚组分析在女性和男性、亚洲和非亚洲国家开展的研究以及前瞻性和回顾性队列中均显示出一致的结果（所有p均>0.05）。仅限于对吸烟状况进行调整的研究的荟萃分析也显示出类似结果（HR：0.91，95% CI：0.80至1.05，p = 0.21；I = 0）。基于Egger回归检验未检测到发表偏倚（p = 0.32）。
队列研究的当前证据不支持MetS是肺癌发病率的独立危险因素。
