Ke Yini, Xu Chengfu, Lin Jin, Li Youming
Department of Rheumatology and Immunology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
J Transl Int Med. 2019 Dec 31;7(4):143-148. doi: 10.2478/jtim-2019-0029. eCollection 2019 Dec.
Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases like type 2 diabetes and obesity. In recent decades, accumulating evidence has revealed that the hepatokines, proteins mainly secreted by the liver, play important roles in the development of NAFLD by acting directly on the lipid and glucose metabolism. As a member of organokines, the hepatokines establish the communication between the liver and the adipose, muscular tissues. In this review, we summarize the current understanding of the hepatokines and how they modulate the pathogenesis of metabolic disorders especially NAFLD.
非酒精性脂肪性肝病（NAFLD）与2型糖尿病和肥胖症等代谢性疾病密切相关。近几十年来，越来越多的证据表明，肝脏分泌的主要蛋白质——肝源性激素，通过直接作用于脂质和葡萄糖代谢，在NAFLD的发展中发挥重要作用。作为器官因子的一员，肝源性激素在肝脏与脂肪组织、肌肉组织之间建立了联系。在这篇综述中，我们总结了目前对肝源性激素的认识，以及它们如何调节代谢紊乱尤其是NAFLD的发病机制。
