Sani Na'imatu A, Kawu Mohammed U, Bako Ibrahim G
Department of Veterinary Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ahmadu Bello University, Zaria, Nigeria.
Int J Vet Sci Med. 2019 Dec 17;7(1):71-77. doi: 10.1080/23144599.2019.1694307. eCollection 2019.
Inadequacy of milk supply to meet the increasing human population coupled with a decreasing livestock population has necessitated the need for a potent galactogoue. The aim of this study was to compare the lactogenic effects of (PLT) and resveratrol in Wistar rats. After parturition, 25 primiparous female Wistar rats were randomly allocated into five groups of 5 dams each. Dams in groups I, II, III, IV and V were administered distilled water (DW: 2 ml/kg), metochlopromide (MET: 15 mg/kg), resveratrol (RES: 5 mg/kg), -hexane leaf fraction of (PLT: 333 mg/kg) and the combination of RES + PLT (CO: 5 mg + 333 mg/kg); respectively, for 12 days. Pup weight gain was used to quantify milk yield. Serum was harvested from the dams and assayed for prolactin and oxytocin. The PLT and CO groups had significantly higher ( < 0.05) milk yield than DW group. Serum concentration of prolactin was significantly higher ( < 0.05) in the PLT group, while the combination group had the highest ( < 0.05) concentration of oxytocin compared to DW group. In conclusion, and resveratrol exhibited galactopoietic potentials individually by stimulating hyperprolactinaemia, while their combination increased milk production by increasing serum oxytocin activity.
牛奶供应不足难以满足不断增长的人口需求，再加上牲畜数量减少，因此需要一种有效的催乳剂。本研究的目的是比较紫锥菊提取物（PLT）和白藜芦醇对Wistar大鼠的催乳作用。分娩后，将25只初产雌性Wistar大鼠随机分为五组，每组5只母鼠。第I、II、III、IV和V组的母鼠分别给予蒸馏水（DW：2 ml/kg）、甲氧氯普胺（MET：15 mg/kg）、白藜芦醇（RES：5 mg/kg）、紫锥菊正己烷叶提取物（PLT：333 mg/kg）以及RES + PLT组合（CO：5 mg + 333 mg/kg），持续给药12天。通过幼崽体重增加来量化产奶量。采集母鼠的血清，检测催乳素和催产素。PLT组和CO组的产奶量显著高于DW组（P < 0.05）。PLT组血清催乳素浓度显著高于DW组（P < 0.05），而与DW组相比，组合组的催产素浓度最高（P < 0.05）。总之, 紫锥菊提取物和白藜芦醇通过刺激高催乳素血症分别表现出催乳潜力，而它们的组合通过增加血清催产素活性提高了产奶量。
