非HIV感染且非移植受者患者肺隐球菌病的术后抗真菌治疗：110例报告及文献综述
Postoperative Antifungal Treatment of Pulmonary Cryptococcosis in Non-HIV-Infected and Non-Transplant-Recipient Patients: A Report of 110 Cases and Literature Review.
作者信息
Wei Shuo, Su Xin, Pan Yun-Hu, Zheng Yuan-Yuan, Dong Xiao-Wen, Hu Xiao-Hua, Wu Fan, Shi Yi
机构信息
Jinling Hospital Department of Respiratory Medicine, Southern Medical University (Guangzhou), Nanjing, China.
Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China.
出版信息
Open Forum Infect Dis. 2020 Jan 13;7(1):ofaa004. doi: 10.1093/ofid/ofaa004. eCollection 2020 Jan.
BACKGROUND
To explore the efficacy of postoperative antifungal treatment for preventing the recurrence of pulmonary cryptococcosis (PC) and occurrence of cryptococcal meningitis (CM), a retrospective study was conducted in 112 hospitalized PC patients with or without antifungal treatment following surgery.
METHODS
The treatment failure rate, PC recurrence rate, and CM incidence were compared. Additionally, the effectiveness of postoperative antifungal therapy was assessed by gathering and analyzing the published literature.
RESULTS
The failure rate (.054) and recurrence rate (.178) were similar in the 2 groups, but the incidence of CM was lower in the group that received postoperative antifungal treatment (.039).
CONCLUSIONS
This study did not show any difference in the PC recurrence rate or failure rate in the different treatment duration groups. Thus, a shorter antifungal treatment course of 2 months may be an optional treatment. In addition, upon review of the literature, no case of CM occurrence was reported among the 169 cases given postoperative antifungal treatment.
背景
为探讨术后抗真菌治疗对预防肺隐球菌病（PC）复发及隐球菌性脑膜炎（CM）发生的疗效，对112例术后接受或未接受抗真菌治疗的住院PC患者进行了一项回顾性研究。
方法
比较治疗失败率、PC复发率和CM发病率。此外，通过收集和分析已发表的文献评估术后抗真菌治疗的有效性。
结果
两组的失败率（0.054）和复发率（0.178）相似，但接受术后抗真菌治疗组的CM发病率较低（0.039）。
结论
本研究未显示不同治疗时长组在PC复发率或失败率上有任何差异。因此，2个月的较短抗真菌治疗疗程可能是一种可选的治疗方法。此外，经文献回顾，在169例接受术后抗真菌治疗的病例中未报告有CM发生的情况。
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