Karadağ Ahmet, Hayta Emrullah, Çelik Veysel Kenan, Bakir Sevtap
Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey.
Department of Physical Medicine and Rehabilitation, Acıbadem Hospital, Istanbul, Turkey.
Arch Rheumatol. 2019 Apr 22;34(4):414-418. doi: 10.5606/ArchRheumatol.2019.7265. eCollection 2019 Dec.
This study aims to compare the serum vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-1 (VEGFR-1) levels between patients with fibromyalgia syndrome (FMS) and healthy controls.
The study included 40 female patients (mean age 39.9±10.2 years; range, 22 to 52 years) diagnosed with primary FMS according to the American College of Rheumatology criteria (1990) and 40 healthy female volunteers (mean age 40.9±8.3 years; range, 25 to 53 years). The sociodemographic data of both groups were recorded. The disease duration and the number of tender points were recorded for patients with FMS, and venous blood samples were collected from the two groups for the measurement of serum VEGF and VEGFR-1 levels.
The FMS and control groups were comparable in terms of age and body mass index (p>0.05). A comparison of the serum VEGF levels of the FMS and control groups revealed a statistically insignificant difference (p>0.05), while a comparison of the serum VEGF-1 levels of the FMS and control groups revealed a statistically significant difference (p<0.05).
Serum VEGFR-1 levels were higher in patients with FMS, while the serum VEGF levels of the FMS patients did not differ from those of the healthy controls.
本研究旨在比较纤维肌痛综合征（FMS）患者与健康对照者血清血管内皮生长因子（VEGF）和血管内皮生长因子受体-1（VEGFR-1）水平。
本研究纳入了40例根据美国风湿病学会标准（1990年）诊断为原发性FMS的女性患者（平均年龄39.9±10.2岁；范围22至52岁）以及40名健康女性志愿者（平均年龄40.9±8.3岁；范围25至53岁）。记录两组的社会人口统计学数据。记录FMS患者的病程和压痛点数量，并采集两组静脉血样以测定血清VEGF和VEGFR-1水平。
FMS组和对照组在年龄和体重指数方面具有可比性（p>0.05）。FMS组和对照组血清VEGF水平比较显示差异无统计学意义（p>0.05），而FMS组和对照组血清VEGFR-1水平比较显示差异有统计学意义（p<0.05）。
FMS患者血清VEGFR-1水平较高，而FMS患者的血清VEGF水平与健康对照者无差异。
