Fidan Fatma, Alkan Berat Meryem, Uğurlu Fatma Gülçin, Bozkurt Sinem, Sezer Nebahat, Biçer Cemile, Erel Özcan, Ardiçoğlu Özge, Akkuş Selami
Department of Physical Medicine and Rehabilitation, Medical Faculty of Yıldırım Beyazıt University, Ankara, Turkey.
Department of Physical Medicine and Rehabilitation, Atatürk Training and Research Hospital, Ankara, Turkey.
Arch Rheumatol. 2017 Jan 18;32(2):112-117. doi: 10.5606/ArchRheumatol.2017.5931. eCollection 2017 Jun.
This study aims to investigate dynamic thiol/disulphide homeostasis in patients with fibromyalgia syndrome (FMS).
Fifty female patients with FMS (mean age 40.5±7.2 years; range 21 to 55 years) and 40 healthy female controls (mean age 39±9.4 years, range 22 to 55 years) were included in the study. Pain visual analog scale, tender points, Fibromyalgia Impact Questionnaire, and Beck Depression Inventory were evaluated. Age, body mass index (BMI), and symptom durations were also recorded. Native thiol, disulphide and total thiol levels were measured with a novel automated method.
Serum disulphide levels were 14.7±3.4 μmol/L and 22.2±3.6 μmol/L in the FMS and control groups, respectively (p<0.001). Native thiol levels were 452.1±33.8 μmol/L and 433.5±37.6 μmol/L in the FMS and control groups, (p=0.015), while total thiol levels were 481.7±35.6 μmol/L and 477.5±38.9 μmol/L in the FMS and control groups, respectively (p=0.593). In the FMS group, disulphide/native thiol percent ratios and disulphide/ total thiol percent ratios were statistically significantly lower and native/total thiol percent ratios were statistically significantly higher than those of the control group. There were no correlations between serum thiol/disulphide profiles and pain scores & clinical variables in patients with FMS.
Because of the decreased disulphide and increased native thiol levels, the thiol/disulphide balance has shifted to the reductive side. This metabolic disturbance may have a role in the pathogenesis of FMS.
本研究旨在调查纤维肌痛综合征（FMS）患者动态硫醇/二硫化物内稳态。
本研究纳入了50名FMS女性患者（平均年龄40.5±7.2岁；年龄范围21至55岁）和40名健康女性对照者（平均年龄39±9.4岁，年龄范围22至55岁）。评估了疼痛视觉模拟量表、压痛点、纤维肌痛影响问卷和贝克抑郁量表。还记录了年龄、体重指数（BMI）和症状持续时间。采用一种新型自动化方法测量天然硫醇、二硫化物和总硫醇水平。
FMS组和对照组的血清二硫化物水平分别为14.7±3.4 μmol/L和22.2±3.6 μmol/L（p<0.001）。FMS组和对照组的天然硫醇水平分别为452.1±33.8 μmol/L和433.5±37.6 μmol/L（p=0.015），而FMS组和对照组的总硫醇水平分别为481.7±35.6 μmol/L和477.5±38.9 μmol/L（p=0.593）。在FMS组中，二硫化物/天然硫醇百分比比值和二硫化物/总硫醇百分比比值在统计学上显著低于对照组，而天然/总硫醇百分比比值在统计学上显著高于对照组。FMS患者的血清硫醇/二硫化物谱与疼痛评分及临床变量之间无相关性。
由于二硫化物水平降低和天然硫醇水平升高，硫醇/二硫化物平衡已向还原侧转移。这种代谢紊乱可能在FMS的发病机制中起作用。
