Florent Guerville, Institut du Vieillissement, Gérontopôle de Toulouse, 37 allée Jules Guesde, 31000 Toulouse, France. Email:
J Prev Alzheimers Dis. 2020;7(1):56-64. doi: 10.14283/jpad.2019.50.
The Geroscience aims at a better understanding of the biological processes of aging, to prevent and/or delay the onset of chronic diseases and disability as well as to reduce the severity of these adverse clinical outcomes. Geroscience thus open up new perspectives of care to live a healthy aging, that is to say without dependency. To date, life expectancy in healthy aging is not increasing as fast as lifespan. The identification of biomarkers of aging is critical to predict adverse outcomes during aging, to implement interventions to reduce them, and to monitor the response to these interventions. In this narrative review, we gathered information about biomarkers of aging under the perspective of Geroscience. Based on the current literature, for each hallmark of biological aging, we proposed a putative biomarker of healthy aging, chosen for their association with mortality, age-related chronic diseases, frailty and/or functional loss. We also discussed how they could be validated as useful predictive biomarkers.
衰老科学旨在更好地理解衰老的生物学过程，预防和/或延迟慢性疾病和残疾的发生，并降低这些不良临床结局的严重程度。因此，衰老科学为健康老龄化提供了新的护理视角，即无需依赖。迄今为止，健康老龄化的预期寿命增长速度不如寿命增长速度快。衰老生物标志物的鉴定对于预测衰老过程中的不良结局、实施干预措施以减少这些结局以及监测这些干预措施的反应至关重要。在这篇叙述性综述中，我们从衰老科学的角度收集了有关衰老生物标志物的信息。根据目前的文献，对于每一个生物学衰老的标志，我们提出了一个假设的健康衰老生物标志物，选择它们是因为它们与死亡率、与年龄相关的慢性疾病、虚弱和/或功能丧失有关。我们还讨论了如何将它们验证为有用的预测生物标志物。
