Zheng Z T, Xing L P
Dept. of Gastroenterology, Third Hospital, Beijing Medical University, People's Republic of China.
Scand J Gastroenterol. 1988 Oct;23(8):1020-4. doi: 10.3109/00365528809090164.
The effect of furazolidone, a monoamine oxidase (MAO) inhibitor, on cysteamine-induced duodenal ulcer and gut catecholamines was studied in rats, since previous reports have suggested protective effects of MAO inhibitors against other forms of experimental mucosal injury. Furazolidone (100 mg kg-1, orally) pretreatment significantly reduced the frequency and severity of cysteamine-induced duodenal ulcer. By means of a spectrofluorometric technique, gastric and duodenal norepinephrine concentrations and duodenal dopamine concentrations were measured and found to be increased in animals treated with the MAO inhibitor. It is concluded that the protective effect of furazolidone against cysteamine-induced duodenal ulcer may in part be related to modulation of gut norepinephrine and dopamine concentrations.
由于先前的报告表明单胺氧化酶（MAO）抑制剂对其他形式的实验性粘膜损伤具有保护作用，因此研究了MAO抑制剂呋喃唑酮对半胱胺诱导的大鼠十二指肠溃疡和肠道儿茶酚胺的影响。呋喃唑酮（100mg/kg，口服）预处理显著降低了半胱胺诱导的十二指肠溃疡的频率和严重程度。通过荧光分光光度技术测量胃和十二指肠去甲肾上腺素浓度以及十二指肠多巴胺浓度，发现用MAO抑制剂处理的动物中这些浓度升高。得出的结论是，呋喃唑酮对半胱胺诱导的十二指肠溃疡的保护作用可能部分与调节肠道去甲肾上腺素和多巴胺浓度有关。
