Ali B H
Department of Pharmacology, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.
Pharmacology. 1991;42(1):49-53. doi: 10.1159/000138767.
The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days signficantly reduced, in a dose-dependent manner, the incidence and extent of cysteamine-induced ulceration. However, oral NF (100 mg/kg) given for 2 consecutive days had no significant effect on duodenal ulceration. The duodenal mucus content of rats was not significantly affected by either FZ or cysteamine treatments. FZ at an oral dose of 100 mg/kg for 2 consecutive days significantly reduced the incidence and extent of indometacin-induced ulceration. Smaller doses of 25 or 50 mg/kg had no significant effects.
本实验研究了硝基呋喃类药物呋喃唑酮（FZ）和呋喃西林（NF）对大鼠半胱胺或吲哚美辛诱导的十二指肠溃疡的保护作用。连续2天口服剂量为25、50或100mg/kg的FZ，以剂量依赖的方式显著降低了半胱胺诱导的溃疡的发生率和严重程度。然而，连续2天口服NF（100mg/kg）对十二指肠溃疡没有显著影响。FZ或半胱胺处理对大鼠十二指肠黏液含量均无显著影响。连续2天口服剂量为100mg/kg的FZ显著降低了吲哚美辛诱导的溃疡的发生率和严重程度。较小剂量25或50mg/kg则无显著影响。
