Bendsten F, Rune S J
Dept. of Gastroenterology, Glostrup Hospital, Denmark.
Scand J Gastroenterol. 1988 Oct;23(8):935-40. doi: 10.3109/00365528809090150.
Gastric and duodenal bulb pH was measured simultaneously with a multiple pH electrode system in 15 duodenal ulcer patients. A single dose of 10 ml antacid was given 120 min after a liquid standard meal, and the pH was measured for another 90 min. The effect of antacid on duodenal pH, expressed as the time pH is kept above 3.0, was on an average 60 min--shorter in patients with a high gastric acid secretion and longer in normosecretors (p less than 0.01). Regression analysis of simultaneously measured gastric and duodenal bulb pH after antacid showed a highly significant linear correlation with a slope of 1.43, which is significantly greater than 1.0 (p less than 0.01), indicating that antacid has a more pronounced effect on duodenal pH than on gastric pH.
用多pH电极系统对15例十二指肠溃疡患者同时测量胃和十二指肠球部的pH值。在给予流质标准餐后120分钟给予10毫升抗酸剂单剂量，然后再测量90分钟的pH值。抗酸剂对十二指肠pH值的影响，以pH值保持在3.0以上的时间表示，平均为60分钟——胃酸分泌高的患者时间较短，正常分泌者时间较长（p<0.01）。抗酸剂后同时测量的胃和十二指肠球部pH值的回归分析显示，线性相关性高度显著，斜率为1.43，显著大于1.0（p<0.01），表明抗酸剂对十二指肠pH值的影响比对胃pH值的影响更明显。
